Carrozzo M, Pellicano R
Department of Oral Medicine, School of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
Minerva Gastroenterol Dietol. 2008 Mar;54(1):65-74.
An association between lichen planus (LP) and liver diseases has been reported. PubMed database has been used to extract information on hepatitis C virus (HCV) infection and LP. The results suggest that LP, mainly the oral type, is significantly associated with HCV infection in Southern Europe and Japan but not in Northern Europe. These differences may be related to genetic factors. Detection of HCV viral sequences and HCV-specific CD4+ and/or CD8+ T lymphocytes in oral samples of LP patients suggests that HCV might be involved in the development of oral lesions via an immunological pathway, characterized by an excessive production of Th1 cytokines following an uneffective antiviral immuno-response.
已有报道称扁平苔藓（LP）与肝脏疾病之间存在关联。已使用PubMed数据库提取有关丙型肝炎病毒（HCV）感染和LP的信息。结果表明，LP，主要是口腔型，在南欧和日本与HCV感染显著相关，但在北欧并非如此。这些差异可能与遗传因素有关。在LP患者的口腔样本中检测到HCV病毒序列以及HCV特异性CD4 +和/或CD8 + T淋巴细胞，表明HCV可能通过免疫途径参与口腔病变的发展，其特征是在无效的抗病毒免疫反应后Th1细胞因子过度产生。
