Salari Pooneh, Rezaie Ali, Larijani Bagher, Abdollahi Mohammad
Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Med Sci Monit. 2008 Mar;14(3):RA37-44.
Osteoporosis, especially in postmenopausal women, delineates a major health and economic problem in the world. Regarding the pathogenesis of osteoporosis and the interaction between various cells and mediators, many studies have been conducted to evaluate the benefit of different therapeutic options. Over the past several years evidence has been growing on the effects of dietary fatty acids on bone health. The objective of this paper was to provide a review of the current knowledge of dietary fatty acids and osteoporosis. Medline/Index Medicus and EMBASE/Excerpta Medica were searched for relevant papers regarding the effects of n-3 fatty acids on osteoporosis between 1963 and 2007 using the key words: osteoporosis, bone health, n-3 fatty acids, and PUFA. Bone mineral density and bone markers have been used in several animal studies to evaluate the beneficial effect of n-3 fatty acids on bone health and the prevention of osteoporosis. Generally, animal studies support the beneficial effects of n-3 fatty acids on bone health and osteoporosis; however, the dissimilar lipid metabolism in human and animals, the various study designs, and controversies over the human study outcomes make it difficult to draw a definite conclusion. The authors believe that conclusive findings in humans are still lacking in this area and it needs to be further investigated.
骨质疏松症，尤其是绝经后女性的骨质疏松症，是全球范围内一个重大的健康和经济问题。关于骨质疏松症的发病机制以及各种细胞与介质之间的相互作用，人们已经开展了许多研究来评估不同治疗方案的益处。在过去几年中，关于膳食脂肪酸对骨骼健康影响的证据不断增加。本文的目的是对膳食脂肪酸与骨质疏松症的现有知识进行综述。利用关键词“骨质疏松症”“骨骼健康”“n-3脂肪酸”和“多不饱和脂肪酸”，检索了1963年至2007年间Medline/医学索引和EMBASE/医学文摘中关于n-3脂肪酸对骨质疏松症影响的相关论文。在多项动物研究中，骨矿物质密度和骨标志物被用于评估n-3脂肪酸对骨骼健康和预防骨质疏松症的有益作用。总体而言，动物研究支持n-3脂肪酸对骨骼健康和骨质疏松症的有益作用；然而，人类和动物不同的脂质代谢、各种研究设计以及人类研究结果的争议使得难以得出明确结论。作者认为，该领域在人类方面仍缺乏确凿的研究结果，需要进一步研究。
