Roosendaal Stefan D, Moraal Bastiaan, Vrenken Hugo, Castelijns Jonas A, Pouwels Petra J W, Barkhof Frederik, Geurts Jeroen J G
Department of Radiology, MS Center Amsterdam, VU University Medical Center, The Netherlands.
J Magn Reson Imaging. 2008 Apr;27(4):726-31. doi: 10.1002/jmri.21294.
To investigate whether a recently improved version of the three-dimensional double inversion-recovery (3D-DIR) technique enables the in vivo detection of hippocampal lesions in multiple sclerosis (MS).
Magnetic resonance images of 16 patients and nine healthy control subjects were acquired at 1.5T. Lesions were scored on 3D-DIR images and were anatomically classified as white matter (WM), cortical, or hippocampal lesions. Associations between hippocampal, cortical, and WM lesion numbers were evaluated. Also, hippocampal lesions were retrospectively assessed on 3D-T2 and hippocampal and brain volumes were measured.
No hippocampal lesions were detected in control subjects. By contrast, 14 out of 16 MS patients had at least one hippocampal lesion. The mean number (+/-SD) of hippocampal lesions detected with 3D-DIR was 2.6 +/- 1.8 in MS patients; only 56% of these lesions could be observed on 3D-T2.
Hippocampal lesions can be visualized in vivo with 3D-DIR and occur frequently in MS. The ability to visualize hippocampal lesions in vivo is of fundamental importance to future studies focusing on the role of gray matter (GM) damage in cognitive deficits, which are common in MS.
研究三维双反转恢复（3D-DIR）技术的最新改进版本是否能够在体内检测多发性硬化症（MS）患者的海马病变。
对16例患者和9名健康对照者进行1.5T磁共振成像检查。在3D-DIR图像上对病变进行评分，并根据解剖学将其分类为白质（WM）、皮质或海马病变。评估海马、皮质和WM病变数量之间的相关性。此外，对3D-T2图像上的海马病变进行回顾性评估，并测量海马和脑体积。
对照者未检测到海马病变。相比之下，16例MS患者中有14例至少有一个海马病变。MS患者中，通过3D-DIR检测到的海马病变平均数量（±标准差）为2.6±1.8个；这些病变中只有56%在3D-T2图像上可见。
3D-DIR能够在体内显示海马病变，且在MS中常见。在体内显示海马病变的能力对于未来聚焦于灰质（GM）损伤在MS常见的认知缺陷中作用的研究至关重要。
