Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, 9500 Euclid Avenue, U-10, Cleveland, OH, 44195, USA.
Neurotherapeutics. 2017 Oct;14(4):905-923. doi: 10.1007/s13311-017-0561-8.
Magnetic resonance imaging has been crucial in the development of anti-inflammatory disease-modifying treatments. The current landscape of multiple sclerosis clinical trials is currently expanding to include testing not only of anti-inflammatory agents, but also neuroprotective, remyelinating, neuromodulating, and restorative therapies. This is especially true of therapies targeting progressive forms of the disease where neurodegeneration is a prominent feature. Imaging techniques of the brain and spinal cord have rapidly evolved in the last decade to permit in vivo characterization of tissue microstructural changes, connectivity, metabolic changes, neuronal loss, glial activity, and demyelination. Advanced magnetic resonance imaging techniques hold significant promise for accelerating the development of different treatment modalities targeting a variety of pathways in MS.
磁共振成像在抗炎疾病修饰治疗的发展中至关重要。目前多发性硬化症临床试验的格局正在扩大，不仅包括抗炎药物的测试，还包括神经保护、髓鞘再生、神经调节和修复治疗。在针对神经退行性变是突出特征的进行性疾病的治疗中尤其如此。在过去十年中，大脑和脊髓的成像技术迅速发展，使得能够在体内对组织微观结构变化、连通性、代谢变化、神经元丧失、神经胶质活性和脱髓鞘进行特征描述。先进的磁共振成像技术为加速针对 MS 中各种途径的不同治疗方式的发展提供了巨大的希望。
