Liu Jingxiu, Wang Xiaoyan, Xie Qing, Liu Yang
School of Public Health, Peking University, Beijing 100083, China.
Wei Sheng Yan Jiu. 2007 Nov;36(6):734-6.
To study the characteristics of content and distribution of light Rare Earth Elements (LREEs) in rat testes.
Based on animal weight, 60 healthy male SD rats were randomly divided into two control groups and four experimental groups. After four week treat, the testes were collected except High-II . The High- II group was freely fed for another four week without the Citrate REEs. The LREE concentrations in the testes were determined by the inductively coupled plasma mass spectrometer (ICP-MS).
(1) The concentrations of LREEs in testes increased with the increase of the doses. The concentrations of LREEs of High-II were much lower than those of High-I significantly (P < 0.05). (2) The distribution patterns of La, Ce, Pr in the testes approximated to the Odd Harkin's rule, but the Nd was an exception (negative deviation). 3. The correlation coefficients of LREEs concentrations between hair and testis were about 0.4, while those between blood and testis were much lower and have no significance.
(1) Dose response relationship could exist in the accumulation of LREEs in the rat testes. (2) Testis could have its own distribution pattern of LREEs. (3) The accumulation of LREEs in testis could be reversible. (4) As it was, a biomarker of the LREEs in hair could be much better than that of blood.
研究大鼠睾丸中轻稀土元素（LREEs）的含量特征及分布情况。
根据动物体重，将60只健康雄性SD大鼠随机分为两个对照组和四个实验组。处理四周后，除高剂量-II组外，其余组收集睾丸。高剂量-II组在无柠檬酸稀土的情况下自由喂养四周。采用电感耦合等离子体质谱仪（ICP-MS）测定睾丸中LREEs的浓度。
（1）睾丸中LREEs的浓度随剂量增加而升高。高剂量-II组LREEs的浓度显著低于高剂量-I组（P<0.05）。（2）睾丸中La、Ce、Pr的分布模式近似于Odd Harkin规则，但Nd除外（负偏差）。（3）毛发与睾丸中LREEs浓度的相关系数约为0.4，而血液与睾丸之间的相关系数则低得多且无统计学意义。
（1）大鼠睾丸中LREEs的蓄积可能存在剂量反应关系。（2）睾丸可能有其自身的LREEs分布模式。（3）睾丸中LREEs的蓄积可能是可逆的。（4）由此可见，毛发中LREEs作为生物标志物可能比血液中的更好。
