Páramo J A, García R, Rodríguez P, Panizo E, Lecumberri R
Servicio de Hematología, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona.
Rev Med Univ Navarra. 2007 Oct-Dec;51(4):38-41.
The antiphospholipid syndrome (APS) is a disorder of recurrent thrombosis and/or pregnancy loss associated with the presence of antiphospholipid antibodies and persistently positive lupus anticoagulant, anticardiolipin or anti beta2-glycoprotein1. Oral anticoagulants are the best available and most effective treatment for the secondary prevention of recurrent venous or arterial thrombosis. Patients with APS are treated with long-term therapy to prolong the INR to 2.0-3.0. Low-molecular-weight heparin in combination with low-aspirin dose is a reasonable strategy to avoid pregnancy loss in women with this syndrome.
抗磷脂综合征（APS）是一种与抗磷脂抗体以及狼疮抗凝物、抗心磷脂或抗β2糖蛋白1持续阳性相关的复发性血栓形成和/或妊娠丢失紊乱疾病。口服抗凝剂是复发性静脉或动脉血栓形成二级预防的最佳可用且最有效治疗方法。APS患者接受长期治疗以使国际标准化比值（INR）延长至2.0 - 3.0。低分子量肝素联合低剂量阿司匹林是避免该综合征女性发生妊娠丢失的合理策略。
