Neumann T
Klinik für Kardiologie, Westdeutsches Herzzentrum Essen, Hufelandstrasse 55, 45122, Essen, Germany.
Internist (Berl). 2008 Apr;49(4):429-30, 432-5. doi: 10.1007/s00108-008-2049-4.
The infection with the human immunodeficiency virus (HIV) is not only associated with a dysfunction of the immune system. Other organs are often affected in patients with HIV-infection, as well. In particular, an increased cardiovascular risk profile leads to an increasing rate of morbidity and mortality due to cardiac disorders, including heart failure and HIV-associated cardiomyopathy in this patient population. However, not only classic risk factors such as smoking, hypertension or dysregulation of lipid and glucose metabolisms are the reasons of HIV-associated myocardial dysfunction. Especially these subjects are also prone to opportunistic infections, side effects of antiretroviral therapy or the HI-virus itself.
人类免疫缺陷病毒(HIV)感染不仅与免疫系统功能障碍有关。HIV感染患者的其他器官也常受到影响。特别是,心血管疾病风险增加导致该患者群体中因心脏疾病(包括心力衰竭和HIV相关心肌病)引起的发病率和死亡率不断上升。然而,HIV相关心肌功能障碍的原因不仅包括吸烟、高血压或脂质与葡萄糖代谢失调等经典风险因素。尤其是这些患者还容易发生机会性感染、抗逆转录病毒治疗的副作用或HIV病毒本身。