高脂饮食可预防并逆转大鼠基于活动的厌食症的发展。
A high-fat diet prevents and reverses the development of activity-based anorexia in rats.
作者信息
Brown Amanda J, Avena Nicole M, Hoebel Bartley G
机构信息
Department of Psychology, Princeton University, Princeton, NJ 08540, USA.
出版信息
Int J Eat Disord. 2008 Jul;41(5):383-9. doi: 10.1002/eat.20510.
Abstract
OBJECTIVE
Activity-based anorexia is an animal model of anorexia nervosa in which limited access to standard lab chow combined with voluntary wheel running leads to hypophagia and severe weight loss. This study tested whether activity-based anorexia could be prevented or reversed with palatable foods.
METHOD
Male rats were divided into sedentary or ad libitum-running groups and maintained on 1 h daily access to standard chow plus one of the following: sugar, saccharin, vegetable fat (shortening), or sweet high-fat chow.
RESULTS
Access to the sweet high-fat chow both reversed and prevented the weight loss typical of activity-based anorexia. Vegetable fat attenuated body weight loss, but to a lesser degree than the sweet high-fat diet. The addition of saccharin or sucrose solutions to the standard lab-chow diet had no effect.
CONCLUSION
The results suggest that certain palatable diets may affect the development of, and recovery from, activity-based anorexia.
摘要
目的
基于活动的厌食症是神经性厌食症的一种动物模型，在该模型中，限制获取标准实验室食物并结合自愿轮转跑步会导致摄食减少和严重体重减轻。本研究测试了美味食物是否可以预防或逆转基于活动的厌食症。
方法
将雄性大鼠分为久坐组或自由跑步组，每天仅1小时可获取标准食物，并搭配以下食物之一：糖、糖精、植物脂肪（起酥油）或甜高脂食物。
结果
获取甜高脂食物既能逆转也能预防基于活动的厌食症典型的体重减轻。植物脂肪减轻了体重下降，但程度小于甜高脂饮食。在标准实验室食物饮食中添加糖精或蔗糖溶液没有效果。
结论
结果表明，某些美味饮食可能会影响基于活动的厌食症的发展和恢复。
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