Huang Cai Guo, Shang Yan Jun, Zhang Jun, Zhang Jian Rong, Li Wen Jie, Jiao Bin Hua
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.
Am J Chin Med. 2008;36(1):149-57. doi: 10.1142/S0192415X08005667.
Phenylpropanoid glycoside acteoside was extracted from the traditional Chinese medicine Scrophularia ningpoenis Hemsl. In the present study, we investigated the effects of acteoside administration on serum uric acid levels in mice rendered hyperuricemic with the uricase inhibitor potassium oxonate. When administered orally for 3 days at doses of 50, 100 and 150 mg/kg, acteoside reduced serum uric acid levels by 15.2, 23.8 and 33.1%, respectively, relative to vehicle-treated hyperuricemic mice. Importantly, in non-hyperuricemic mice, the serum uric acid levels were not affected by acetoside treatment. Acteoside also inhibited mouse liver xanthine dehydrogenase XDH and xanthine oxidase XO activity at all three doses. These results suggest that the hypouricemic action of acteoside may be attributable to its inhibition of XDH/XO activity.
苯丙素苷类化合物毛蕊花糖苷是从传统中药玄参中提取的。在本研究中，我们研究了给予毛蕊花糖苷对用尿酸酶抑制剂氧嗪酸钾诱导的高尿酸血症小鼠血清尿酸水平的影响。当以50、100和150mg/kg的剂量口服给药3天时，相对于载体处理的高尿酸血症小鼠，毛蕊花糖苷分别使血清尿酸水平降低了15.2%、23.8%和33.1%。重要的是，在非高尿酸血症小鼠中，血清尿酸水平不受毛蕊花糖苷处理的影响。在所有三个剂量下，毛蕊花糖苷还抑制小鼠肝脏黄嘌呤脱氢酶（XDH）和黄嘌呤氧化酶（XO）的活性。这些结果表明，毛蕊花糖苷的降尿酸作用可能归因于其对XDH/XO活性的抑制。
