Rosenblum M, Weller R S, Conard P L, Falvey E A, Gross J B
Department of Anesthesiology, University of Connecticut School of Medicine, Farmington 06032.
Anesth Analg. 1991 Sep;73(3):255-9. doi: 10.1213/00000539-199109000-00004.
The authors compared the analgesic efficacy of one dose of oral ibuprofen with that of intravenously administered fentanyl for relief of pain after outpatient laparoscopic surgery. Thirty healthy female patients received either 800 mg of oral ibuprofen preoperatively or 75 micrograms of intravenous fentanyl intraoperatively plus respective intravenous or oral placebos in a randomized, double-blind manner. Patients recorded their degree of pain and nausea in the recovery room, in the same-day surgery stepdown unit, during the ride home, and upon arrival at home. The postanesthesia care nurse recorded the amount of fentanyl and droperidol needed to treat pain and nausea in the recovery room. Patients who received ibuprofen were more comfortable in the stepdown unit (P less than 0.05) and after arrival home (P less than 0.05) than those in the fentanyl group. Additionally, patients who received ibuprofen had lower nausea scores in the step-down unit (P less than 0.05); this may have been related to the lower total fentanyl dose in these patients. The authors conclude that ibuprofen may be a useful alternative to fentanyl for providing postoperative analgesia for outpatient surgery.
作者比较了单剂量口服布洛芬与静脉注射芬太尼对门诊腹腔镜手术后疼痛的镇痛效果。30名健康女性患者以随机、双盲方式，术前接受800毫克口服布洛芬，或术中接受75微克静脉注射芬太尼，并分别给予静脉或口服安慰剂。患者记录了在恢复室、当日手术观察病房、回家途中及到家时的疼痛程度和恶心情况。麻醉后护理护士记录了在恢复室治疗疼痛和恶心所需的芬太尼和氟哌利多的用量。接受布洛芬治疗的患者在观察病房（P<0.05）和到家后（P<0.05）比芬太尼组患者感觉更舒适。此外，接受布洛芬治疗的患者在观察病房的恶心评分较低（P<0.05）；这可能与这些患者较低的芬太尼总剂量有关。作者得出结论，布洛芬可能是芬太尼的一种有用替代品，可为门诊手术提供术后镇痛。
