Piani Cecilia, Franchi Giulia M, Cappelletti Chiara, Scavini Marina, Albarello Luca, Zerbi Alessandro, Giorgio Arcidiacono Paolo, Bosi Emanuele, Manzoni Marco F
General Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute, Università Vita-Salute San Raffaele, Via Olgettina 60, Milano, Italy.
Endocr Relat Cancer. 2008 Mar;15(1):175-81. doi: 10.1677/ERC-07-0126.
The cytological Ki-67 expression measured on cytological samples collected by endoscopic ultrasonography-guided fine needle aspiration cytology (EUS-FNAC) may provide pre-operative indications for pancreatic endocrine tumours (PETs) management. The aim of our study was to assess reliability of Ki-67 expression measured on cytological samples obtained by EUS-FNAC in patients with PETs. Eighteen patients with PETs underwent EUS-FNAC before surgery. Ki-67 expression was measured on FNACs and on histological sections. Using a cut-off of 2%, percent agreement of Ki-67 expression on cytological and histological samples was 89% (k-statistic: 0.78, 95% confidence intervals (95% CI): 0.5, 1.0). Using cut-off values of 2 and 10%, percent agreement was 78% (k-statistic: 0.65, 95% CI: 0.3, 0.9). Ki-67 expression measured on cytological samples obtained by EUS-FNAC before surgery showed good agreement with that measured on histological samples.
通过超声内镜引导下细针穿刺细胞学检查（EUS-FNAC）采集的细胞学样本中检测到的Ki-67表达，可为胰腺内分泌肿瘤（PET）的治疗提供术前指征。我们研究的目的是评估在PET患者中，通过EUS-FNAC获得的细胞学样本中检测到的Ki-67表达的可靠性。18例PET患者在手术前行EUS-FNAC检查。在细针穿刺活检样本和组织学切片上检测Ki-67表达。采用2%的临界值，细胞学和组织学样本中Ki-67表达的一致性百分比为89%（k统计量：0.78，95%置信区间（95%CI）：0.5，1.0）。采用2%和10%的临界值，一致性百分比为78%（k统计量：0.65，95%CI：0.3，0.9）。术前通过EUS-FNAC获得的细胞学样本中检测到的Ki-67表达与组织学样本中检测到的Ki-67表达具有良好的一致性。
