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白细胞介素-1受体拮抗剂（IL-1RN）和白细胞介素-10多态性与银屑病风险的关联性缺失：一项荟萃分析。

Lack of association of the IL-1RN and IL-10 polymorphisms with risk of psoriasis: A meta-analysis.

作者信息

Qiao Ju, Jia Qian-Nan, Jin Hong-Zhong

机构信息

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Mol Genet Genomic Med. 2019 Jan;7(1):e00512. doi: 10.1002/mgg3.512. Epub 2018 Dec 6.

DOI:10.1002/mgg3.512
PMID:30523673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6382441/
Abstract

BACKGROUND

The present study carried out a meta-analysis to investigate whether the interleukin-1 receptor antagonist (IL-1RN) VNTR polymorphism and three IL-10 single-nucleotide polymorphisms (SNPs) rs1800896, rs3021097, and rs1800872 are associated with psoriasis risk.

METHODS

Wanfang, China National Knowledge Infrastructure, Medline, and PubMed databases were searched for potential studies published until 2 November 2017. Forest plots were generated.

RESULTS

Thirteen case-control studies were included in the review. The results of meta-analyses revealed no association of the IL-1RN*2 allele with psoriasis in the overall populations (odds ratio [OR] = 1.16, 95% confidence intervals [CI]: 0.89-1.50, p = 0.279), Asians (OR = 1.27, 95% CI: 0.73-2.23, p = 0.403), and Caucasians (OR = 1.04, 95% CI: 0.88-1.23, p = 0.669). Under the allelic model, there was no statistically significant association of psoriasis with the IL-10 SNPs rs1800896 (G allele vs. A allele: OR = 1.03, 95% CI: 0.90-1.18, p = 0.639), rs3021097 (C allele vs. T allele: OR = 1.17, 95% CI: 0.88-1.56, p = 0.288), and rs1800872 (C allele vs. A allele: OR = 1.01, 95% CI: 0.81-1.25, p = 0.951). No publication bias was found by Egger's test and Begg's funnel plots.

CONCLUSION

Current published studies fail to support an association of the IL-1RN VNTR polymorphism and IL-10 SNPs rs1800896, rs3021097, and rs1800872 with psoriasis risk.

摘要

背景

本研究进行了一项荟萃分析，以调查白细胞介素-1受体拮抗剂（IL-1RN）可变数目串联重复序列（VNTR）多态性以及白细胞介素-10的三个单核苷酸多态性（SNP）rs1800896、rs3021097和rs1800872是否与银屑病风险相关。

方法

检索万方、中国知网、Medline和PubMed数据库，查找截至2017年11月2日发表的相关潜在研究。绘制森林图。

结果

该综述纳入了13项病例对照研究。荟萃分析结果显示，在总体人群（优势比[OR]=1.16，95%置信区间[CI]：0.89-1.50，p=0.279）、亚洲人群（OR=1.27，95%CI：0.73-2.23，p=0.403）和高加索人群（OR=1.04，95%CI：0.88-1.23，p=0.669）中，IL-1RN*2等位基因与银屑病均无关联。在等位基因模型下，银屑病与IL-10的SNP rs1800896（G等位基因与A等位基因：OR=1.03，95%CI：0.90-1.18，p=0.639）、rs3021097（C等位基因与T等位基因：OR=1.17，95%CI：0.88-1.56，p=0.288）和rs1800872（C等位基因与A等位基因：OR=1.01，95%CI：0.81-1.25，p=0.951）均无统计学显著关联。通过Egger检验和Begg漏斗图未发现发表偏倚。

结论

目前已发表的研究未能支持IL-1RN VNTR多态性以及IL-10的SNP rs1800896、rs3021097和rs1800872与银屑病风险存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/b1ee977fc925/MGG3-7-na-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/2143a96c1380/MGG3-7-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/9b26b66908b5/MGG3-7-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/31837ca73fef/MGG3-7-na-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/7d96f0e89d0f/MGG3-7-na-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/c04df4bd5ffc/MGG3-7-na-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/b1ee977fc925/MGG3-7-na-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/2143a96c1380/MGG3-7-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/9b26b66908b5/MGG3-7-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/31837ca73fef/MGG3-7-na-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/7d96f0e89d0f/MGG3-7-na-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/c04df4bd5ffc/MGG3-7-na-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a0d/6382441/b1ee977fc925/MGG3-7-na-g006.jpg

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本文引用的文献

1
Interleukin-1 Blockade: An Update on Emerging Indications.白细胞介素-1 阻断：新兴适应证的最新进展。
BioDrugs. 2017 Jun;31(3):207-221. doi: 10.1007/s40259-017-0224-7.
2
Diagnosis and management of psoriasis.银屑病的诊断与管理
Can Fam Physician. 2017 Apr;63(4):278-285.
3
T helper-2 cytokine/regulatory T-cell gene polymorphisms and their relation with risk of psoriasis in a South Indian Tamil cohort.南印度泰米尔人群中辅助性T细胞2细胞因子/调节性T细胞基因多态性及其与银屑病风险的关系。
白细胞介素1受体拮抗剂基因串联重复序列多态性与皮肤黑色素瘤
Oncol Lett. 2019 Dec;18(6):5759-5768. doi: 10.3892/ol.2019.10923. Epub 2019 Sep 25.
Hum Immunol. 2017 Feb;78(2):209-215. doi: 10.1016/j.humimm.2016.12.006. Epub 2016 Dec 24.
4
Regulation of Interleukin-10 Expression.白细胞介素-10 表达的调控。
Adv Exp Med Biol. 2016;941:89-116. doi: 10.1007/978-94-024-0921-5_5.
5
Interleukin 1α and the inflammatory process.白细胞介素1α与炎症过程。
Nat Immunol. 2016 Jul 19;17(8):906-13. doi: 10.1038/ni.3503.
6
IL-10-producing regulatory B cells are decreased in patients with psoriasis.银屑病患者中产生白细胞介素-10的调节性B细胞数量减少。
J Dermatol Sci. 2016 Feb;81(2):93-100. doi: 10.1016/j.jdermsci.2015.11.003. Epub 2015 Nov 14.
7
Update on psoriasis immunopathogenesis and targeted immunotherapy.银屑病免疫发病机制及靶向免疫治疗的最新进展
Semin Immunopathol. 2016 Jan;38(1):11-27. doi: 10.1007/s00281-015-0539-8. Epub 2015 Nov 16.
8
Interleukin-1 Gene Polymorphisms and their Relation with NFκB Expression and Histopathological Features in Psoriasis.白细胞介素-1基因多态性及其与银屑病中NFκB表达和组织病理学特征的关系
Indian J Dermatol. 2015 Sep-Oct;60(5):432-8. doi: 10.4103/0019-5154.159630.
9
B cells expressing IL-10 mRNA modulate memory T cells after DNA-Hsp65 immunization.表达白细胞介素-10信使核糖核酸的B细胞在DNA-热休克蛋白65免疫后调节记忆性T细胞。
Braz J Med Biol Res. 2015 Dec;48(12):1095-100. doi: 10.1590/1414-431X20154409. Epub 2015 Sep 18.
10
Psoriasis.银屑病。
Lancet. 2015 Sep 5;386(9997):983-94. doi: 10.1016/S0140-6736(14)61909-7. Epub 2015 May 27.