Manz B, Benecke M, Volke F
Arbeitsgruppe Magnetische Resonanz, Fraunhofer-Institut für Biomedizinische Technik, Ensheimer Strasse 48, 66386 St. Ingbert, Germany.
J Magn Reson. 2008 May;192(1):131-8. doi: 10.1016/j.jmr.2008.02.011. Epub 2008 Feb 15.
A new portable, pocket-size NMR probe based on a novel permanent magnet arrangement is presented. It is based on a Halbach-type magnet design which mimics the field of a spherical dipole by using cylindrical bar and ring magnets. The magnet system is made up of only three individual magnets, and most field calculations and optimisations can be performed analytically. A prototype system has been built using a set of small, off the shelf commercially available permanent magnets. Proton linewidths of 50 ppm FWHM could be achieved at a field strength of 1T. Calculations show that with custom-sized permanent magnets, linewidths of less than 1 ppm can be achieved over sample volumes of up to 1 mm3, which would in theory enable chemical shift resolved proton spectroscopy on mass-limited samples. But even with the achieved linewidth of 50 ppm, this can be a useful portable sensor for small amounts of liquid samples with restricted molecular mobility, like gels, polymers or high viscosity liquids.
本文介绍了一种基于新型永磁体排列的新型便携式袖珍核磁共振探头。它基于哈尔巴赫型磁体设计,通过使用圆柱形棒状磁体和环形磁体来模拟球形偶极子的磁场。磁体系统仅由三个单独的磁体组成,并且大多数场计算和优化都可以通过解析方法进行。使用一组小型的、市售的现成永磁体构建了一个原型系统。在1T的场强下,可以实现50 ppm半高宽的质子线宽。计算表明,使用定制尺寸的永磁体,在高达1 mm3的样品体积上可以实现小于1 ppm的线宽,这在理论上能够对质量受限的样品进行化学位移分辨质子光谱分析。但即使达到50 ppm的线宽,对于分子流动性受限的少量液体样品,如凝胶、聚合物或高粘度液体,这仍然可以是一种有用的便携式传感器。