Feusner Jamie D, Yaryura-Tobias Jose, Saxena Sanjaya
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, David Geffen School of Medicine at UCLA, CA, USA.
Body Image. 2008 Mar;5(1):3-12. doi: 10.1016/j.bodyim.2007.11.002. Epub 2008 Mar 7.
Body dysmorphic disorder (BDD) is an often severe and disabling condition, affecting up to 2% of the population. Despite its prevalence and clinical significance, very little is known about the pathophysiology of BDD. However, clues to its possible neurobiological substrates and abnormalities in information processing are starting to emerge. This article reviews findings from genetic, brain lesion, neuroimaging, neuropsychological, and psychopharmacological studies that have allowed us to develop a tentative model of the functional neuroanatomy of BDD. There is likely a complex interplay of dysfunctions in several brain networks underlying the pathophysiology of BDD. A combination of dysfunctions in frontal-subcortical circuits, temporal, parietal, and limbic structures, and possibly involving hemispheric imbalances in information processing, may produce both the characteristic symptoms and neurocognitive deficits seen in BDD. An improved understanding of the pathophysiology of BDD will be crucial to guide the development of better treatments.
躯体变形障碍（BDD）是一种通常较为严重且会导致功能障碍的疾病，影响着多达2%的人群。尽管其患病率和临床意义重大，但人们对BDD的病理生理学知之甚少。然而，关于其可能的神经生物学基础以及信息处理异常的线索正开始显现。本文回顾了来自遗传学、脑损伤、神经影像学、神经心理学和精神药理学研究的结果，这些研究使我们能够构建一个关于BDD功能性神经解剖学的初步模型。BDD的病理生理学可能涉及多个脑网络功能障碍之间的复杂相互作用。额叶 - 皮质下回路、颞叶、顶叶和边缘结构的功能障碍组合，可能还涉及信息处理中的半球失衡，可能会产生BDD中出现的典型症状和神经认知缺陷。更好地理解BDD的病理生理学对于指导开发更好的治疗方法至关重要。
