Schienle Anne, Schäfer Axel, Stark Rudolf, Walter Bertram, Vaitl Dieter
Bender Institute of Neuroimaging, University of Giessen, Germany, Department of Psychology, University of Trier, Germany.
Int J Psychophysiol. 2005 Jul;57(1):69-77. doi: 10.1016/j.ijpsycho.2004.12.013. Epub 2005 Apr 22.
This functional magnetic resonance imaging study investigated the disgust- and fear-reactivity of patients suffering from obsessive-compulsive disorder (OCD). Ten OCD patients were scanned while viewing blocks of pictures showing OCD triggers from their personal environment and OCD-irrelevant disgust-inducing, fear-inducing and neutral scenes. Afterwards, the patients rated the intensity of the induced disgust, fear and OCD symptoms. The responses were compared with those of 10 healthy control subjects. The disorder-relevant pictures provoked intense OCD symptoms in the clinical group associated with increased activation in the bilateral prefrontal cortex, the left insula, the right supramarginal gyrus, the left caudate nucleus and the right thalamus. The patients gave higher disgust and fear ratings than the controls for all aversive picture categories. Neural responses towards the disorder-irrelevant disgusting and fear-inducing material included more pronounced insula activation in patients than controls. Summarizing, photos of individual OCD-triggers are an effective means of symptom provocation and activation of the fronto-striato-thalamo-parietal network. The increased insular reactivity of OCD patients during all aversive picture conditions might mirror their susceptibility to experience negative somatic states.
这项功能磁共振成像研究调查了强迫症（OCD）患者对厌恶和恐惧的反应性。在10名强迫症患者观看展示来自其个人环境中的强迫症触发因素以及与强迫症无关的厌恶诱导、恐惧诱导和中性场景的图片组时，对他们进行了扫描。之后，患者对诱发的厌恶、恐惧和强迫症症状的强度进行了评分。将这些反应与10名健康对照受试者的反应进行了比较。与疾病相关的图片在临床组中引发了强烈的强迫症症状，同时双侧前额叶皮质、左侧脑岛、右侧缘上回、左侧尾状核和右侧丘脑的激活增加。对于所有厌恶图片类别，患者给出的厌恶和恐惧评分均高于对照组。与疾病无关的令人厌恶和恐惧诱导材料的神经反应包括患者比对照组更明显的脑岛激活。总之，个体强迫症触发因素的照片是症状激发和激活额-纹状体-丘脑-顶叶网络的有效手段。在所有厌恶图片条件下，强迫症患者脑岛反应性增加可能反映了他们体验负面躯体状态的易感性。
