Paik Kwang Yeol, Heo Jin Seok, Choi Seong Ho, Choi Dong Wook
Department of Surgery, Hanil General Hospital, Seoul, Korea.
J Surg Oncol. 2008 May 1;97(6):508-12. doi: 10.1002/jso.20994.
Intraductal papillary neoplasm of the bile ducts (IPN-B) is considered an uncommon tumor. The purpose of this study was to evaluate the clinical, radiological, and histopathological characteristics of IPN-B, and its prognosis.
From October 1995 to August 2006, a retrospective analysis was made of 25 patients that underwent surgery for IPN-B. Clinical features and radiological, pathological, and operative findings were reviewed, and survival rates were determined.
In five patients (20.0%), lesions were incidentally found. Radiologically, 23 of the 25 (92.0%) showed bile duct dilatation, bile duct dilatation with or without an intraductal mass, and cystic changes of bile ducts. Twenty three of the 25 patients underwent hepatic resection with or without extrahepatic bile duct resection. No in hospital mortality occurred. Median survival time of resected patients was 59.8 months and 1-, 2-, and 4-year survival rates were 90.5%, 84.0%, and 84.0%, respectively. All six patients with benign IPN-B remained alive at a mean of 26.2 postoperative months without recurrence.
A diagnosis of IPN-B is usually made in patients with biliary dilatation by radiologic study. The prognosis of IPN-B, especially of the benign category, is excellent. Aggressive surgical resection is the treatment of choice for IPN-B.
胆管内乳头状肿瘤（IPN - B）被认为是一种罕见肿瘤。本研究旨在评估IPN - B的临床、影像学及组织病理学特征及其预后。
对1995年10月至2006年8月期间接受IPN - B手术的25例患者进行回顾性分析。回顾临床特征、影像学、病理学及手术所见，并确定生存率。
5例患者（20.0%）病变为偶然发现。影像学上，25例中有23例（92.0%）表现为胆管扩张、伴有或不伴有胆管内肿块的胆管扩张以及胆管囊性改变。25例患者中有23例行肝切除，伴或不伴肝外胆管切除。无院内死亡发生。接受手术患者的中位生存时间为59.8个月，1年、2年和4年生存率分别为90.5%、84.0%和84.0%。所有6例良性IPN - B患者术后平均26.2个月仍存活，无复发。
IPN - B的诊断通常通过影像学检查在胆管扩张患者中做出。IPN - B的预后，尤其是良性类型，非常好。积极的手术切除是IPN - B的首选治疗方法。
