Sergerie Karine, Chochol Caroline, Armony Jorge L
Douglas Mental Health University Institute, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3.
Neurosci Biobehav Rev. 2008;32(4):811-30. doi: 10.1016/j.neubiorev.2007.12.002. Epub 2008 Jan 17.
Functional neuroimaging studies have provided strong support for a critical role of the amygdala in emotional processing. However, several controversies remain in terms of whether different factors-such as sex, valence and stimulus type-have an effect on the magnitude and lateralization of amygdala responses. To address these issues, we conducted a meta-analysis of functional neuroimaging studies of visual emotional perception that reported amygdala activation. Critically, unlike previous neuroimaging meta-analyses, we took into account the magnitude (effect size) and reliability (variance) associated with each of the activations. Our results confirm that the amygdala responds to both positive and negative stimuli, with a preference for faces depicting emotional expressions. We did not find evidence for amygdala lateralization as a function of sex or valence. Instead, our findings provide strong support for a functional dissociation between left and right amygdala in terms of temporal dynamics. Taken together, results from this meta-analysis shed new light on several of the models proposed in the literature regarding the neural basis of emotional processing.
功能神经影像学研究为杏仁核在情绪加工中的关键作用提供了有力支持。然而，在诸如性别、效价和刺激类型等不同因素是否会对杏仁核反应的强度和偏侧化产生影响方面，仍存在一些争议。为了解决这些问题，我们对报告杏仁核激活的视觉情绪感知功能神经影像学研究进行了一项荟萃分析。至关重要的是，与以往的神经影像学荟萃分析不同，我们考虑了与每次激活相关的强度（效应大小）和可靠性（方差）。我们的结果证实，杏仁核对积极和消极刺激均有反应，且更倾向于对描绘情绪表情的面孔做出反应。我们没有发现证据表明杏仁核偏侧化是性别或效价的函数。相反，我们的研究结果为左右杏仁核在时间动态方面的功能分离提供了有力支持。综上所述，这项荟萃分析的结果为文献中提出的关于情绪加工神经基础的几种模型提供了新的见解。
