Misra Anoop, Alappan Narendra K, Vikram Naval K, Goel Kashish, Gupta Nidhi, Mittal Kanchan, Bhatt Suryaprakash, Luthra Kalpana
Department of Diabetes and Metabolic Diseases, Fortis Flt. Lt. Rajan Dhall Hospital, New Delhi, India.
Diabetes Care. 2008 Jul;31(7):1282-7. doi: 10.2337/dc07-2316. Epub 2008 Mar 3.
To evaluate the effect of supervised progressive resistance-exercise training (PRT) protocol on insulin sensitivity, glycemia (blood glucose and A1C levels), lipids, and body composition in Asian Indians with type 2 diabetes.
Thirty patients with type 2 diabetes underwent 12 weeks of PRT of six muscle groups (two sets, 10 repetitions each). The subjects were evaluated with detailed anthropometry and with measurements of the disappearance of glucose per unit time (K) during the short insulin tolerance test (K(ITT)) for assessment of insulin sensitivity; of fasting blood glucose, A1C, lipids, and high-sensitivity C-reactive protein (hsCRP); of total body fat, regional fat, and lean body mass by dual-energy X-ray absorptiometry; and of cross-sectional skeletal muscle area of upper arm and thigh by computed tomography scan.
Insulin sensitivity improved significantly from mean +/- SD K(ITT) 1.22 +/- 0.73 to 2.13 +/- 0.75 (P < 0.0001) after the intervention. Significant decline (mean difference +/- SD) from baseline was recorded in levels of the following parameters: A1C (0.54 +/- 0.4%, P < 0.001), fasting blood glucose (2.7 +/- 2.2 mmol/l, P < 0.001), total cholesterol (0.39 +/- 0.7 mmol/l, P = 0.003), serum triglycerides (0.39 +/- 0.5 mmol/l, P < 0.001), and truncal and peripheral subcutaneous adipose tissue compartments (SCAT) (P < 0.001). However, no significant changes were noticed in BMI or levels of total body fat, truncal fat, lean body mass, cross-sectional skeletal muscle area of the extremities, or hsCRP levels.
Moderate-intensity PRT for 3 months resulted in significant improvement in insulin sensitivity, glycemia, lipids, and truncal and peripheral SCAT in patients with type 2 diabetes. Resistance training should be an integral part of exercise regimen in Asian Indians with type 2 diabetes.
评估有监督的渐进性抗阻运动训练（PRT）方案对患有2型糖尿病的亚洲印度人的胰岛素敏感性、血糖（血糖和糖化血红蛋白水平）、血脂及身体成分的影响。
30例2型糖尿病患者对六个肌肉群进行了为期12周的PRT训练（两组，每组10次重复）。通过详细的人体测量以及在短胰岛素耐量试验（K(ITT)）期间测量单位时间内葡萄糖的消失率（K）来评估胰岛素敏感性；测量空腹血糖、糖化血红蛋白、血脂和高敏C反应蛋白（hsCRP）；通过双能X线吸收法测量全身脂肪、局部脂肪和瘦体重；通过计算机断层扫描测量上臂和大腿的横截面骨骼肌面积。
干预后，胰岛素敏感性显著改善，平均±标准差K(ITT)从1.22±0.73提高到2.13±0.75（P<0.0001）。以下参数水平与基线相比有显著下降（平均差值±标准差）：糖化血红蛋白（0.54±0.4%，P<0.001）、空腹血糖（2.7±2.2 mmol/l，P<0.001）、总胆固醇（0.39±0.7 mmol/l，P = 0.003）、血清甘油三酯（0.39±0.5 mmol/l，P<0.001）以及躯干和外周皮下脂肪组织区（SCAT）（P<0.001）。然而，体重指数或全身脂肪、躯干脂肪、瘦体重、四肢横截面骨骼肌面积或hsCRP水平未发现显著变化。
对2型糖尿病患者进行为期3个月的中等强度PRT可显著改善胰岛素敏感性、血糖、血脂以及躯干和外周SCAT。抗阻训练应成为患有2型糖尿病的亚洲印度人运动方案的一个组成部分。
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