Wels Jared, Kaplan Rosandra N, Rafii Shahin, Lyden David
Department of Pediatrics, Weill Cornell Medical College, New York, NY 10021, USA.
Genes Dev. 2008 Mar 1;22(5):559-74. doi: 10.1101/gad.1636908.
The cancer environment is comprised of tumor cells as well as a wide network of stromal and vascular cells participating in the cellular and molecular events necessary for invasion and metastasis. Tumor secretory factors can activate the migration of host cells, both near to and far from the primary tumor site, as well as promote the exodus of cells to distant tissues. Thus, the migration of stromal cells and tumor cells among specialized microenvironments takes place throughout tumor and metastatic progression, providing evidence for the systemic nature of a malignancy. Investigations of the tumor-stromal and stromal-stromal cross-talk involved in cellular migration in cancer may lead to the design of novel therapeutic strategies.
癌症环境由肿瘤细胞以及广泛的基质和血管细胞网络组成，这些细胞参与侵袭和转移所需的细胞和分子事件。肿瘤分泌因子可激活宿主细胞的迁移，包括靠近和远离原发性肿瘤部位的细胞，还能促进细胞向远处组织的迁出。因此，在肿瘤和转移进展过程中，基质细胞和肿瘤细胞在特定微环境之间的迁移不断发生，这为恶性肿瘤的系统性本质提供了证据。对癌症中细胞迁移所涉及的肿瘤-基质和基质-基质相互作用的研究可能会带来新型治疗策略的设计。
