脂溢性皮炎患者血液中维生素E、磷脂多不饱和脂肪酸、脂质过氧化物和谷胱甘肽过氧化物酶的水平。

Blood levels of vitamin E, polyunsaturated fatty acids of phospholipids, lipoperoxides and glutathione peroxidase in patients affected with seborrheic dermatitis.

作者信息

Passi S, Morrone A, De Luca C, Picardo M, Ippolito F

机构信息

Istituto Dermatologico San Gallicano, Rome, Italy.

出版信息

J Dermatol Sci. 1991 May;2(3):171-8. doi: 10.1016/0923-1811(91)90064-5.

DOI:10.1016/0923-1811(91)90064-5

PMID:1831657

Abstract

Plasma levels of vitamin E (Vit E) and polyunsaturated fatty acids of phospholipids (PUFA-PL) as well as erythrocyte glutathione peroxidase (GSH-Px) activity are significantly lower (P less than 0.001) in patients with seborrheic dermatitis (SD). both HIV seropositive or HIV sero-negative, than in control subjects. No differences are found between HIV sero-positive and sero-negative individuals with SD. The deficiency of PUFA-PL (mainly C20: 3 n-6, C20: 4 n-6 and C22: 6 n-3) which is accompanied by a significant increase of saturated palmitic and stearic acids (P less than 0.001), does not appear to be associated with an active lipoperoxidative process in the plasma. The significant blood deficiency of Vit E, GSH-Px, and particularly of PUFA-PL, may play a pathogenetic role in seborrheic dermatitis.

摘要

脂溢性皮炎（SD）患者，无论HIV血清阳性还是HIV血清阴性，其血浆维生素E（Vit E）水平、磷脂多不饱和脂肪酸（PUFA-PL）水平以及红细胞谷胱甘肽过氧化物酶（GSH-Px）活性均显著低于（P<0.001）对照受试者。SD的HIV血清阳性个体与血清阴性个体之间未发现差异。PUFA-PL（主要为C20:3 n-6、C20:4 n-6和C22:6 n-3）缺乏，并伴有饱和棕榈酸和硬脂酸显著增加（P<0.001），但这似乎与血浆中活跃的脂质过氧化过程无关。Vit E、GSH-Px尤其是PUFA-PL的显著血液缺乏，可能在脂溢性皮炎的发病机制中起作用。