Freyria A M, Chignier E, Guidollet J, Louisot P
INSERM U 37, Bron, France.
Biomaterials. 1991 Mar;12(2):111-8. doi: 10.1016/0142-9612(91)90187-f.
This study was designed to validate an in vivo model in rat to study cell-implant interactions. Pieces of Dacron and Goretex and polydimethylsiloxane (reference material) precoated or not were implanted in the peritoneal cavity. In some cases the peritoneal cells were stimulated before the implantation. Macrophage phagocytosis and fibrinocoagulolytic activities were investigated in parallel with morphological studies 6 h after implantation. A graded cell response related to the different situations was observed, providing a measure of the material's behaviour. Using this model, other investigations of macrophage/polymer can be conducted, especially to explain implant encapsulation.
本研究旨在验证一种大鼠体内模型，以研究细胞与植入物的相互作用。将预涂或未预涂的涤纶片、戈尔特斯片和聚二甲基硅氧烷（参考材料）植入腹腔。在某些情况下，在植入前刺激腹膜细胞。在植入后6小时，结合形态学研究，并行研究巨噬细胞吞噬作用和纤维蛋白溶解活性。观察到与不同情况相关的分级细胞反应，这为评估材料的行为提供了一种方法。利用该模型，可以对巨噬细胞/聚合物进行其他研究，特别是用于解释植入物的包封情况。
