Del Popolo G, Mosiello G, Pilati C, Lamartina M, Battaglino F, Buffa P, Redaelli T, Lamberti G, Menarini M, Di Benedetto P, De Gennaro M
Neuro-Urology Spinal Unit, University of Florence, Florence, Italy.
Spinal Cord. 2008 Jul;46(7):517-22. doi: 10.1038/sj.sc.3102167. Epub 2008 Mar 4.
Thirty-six patients with unsatisfactory treatment of neurogenic bowel dysfunctions (NBD) were enrolled from Spinal Units and Rehabilitation Centers in Italy. Treatment was for 3 weeks using a newly developed integrated system with an enema continence catheter for transanal irrigation (Peristeen, Coloplast A/S Kokkedal Denmark).
To evaluate the effects of Peristeen Anal Irrigation on NBD and patient quality of life (QoL).
Italy.
Lesion level, ambulatory status and hand functionality were determined in all patients. NBD symptoms and QoL were evaluated before and after treatment, using a specific questionnaire. Statistical analysis was performed using McNemar Test and Sign Test.
Thirty-six patients were enrolled, and 32 patients completed the study. At the end of the treatment, 28.6% of patients reduced or eliminated their use of pharmaceuticals. Twenty-four patients became less dependent on their caregiver. There was a significant increase in patients' opinion of their intestinal functionality (P=0.001), QoL score (P=0.001) and their answers regarding their degree of satisfaction (P=0.001). A successful outcome was recorded for 68% of patients with fecal incontinence, and for 63% of patients with constipation.
Peristeen Anal Irrigation is a simple therapeutic method for managing NBD and improving QoL. It should be considered as the treatment of choice for NBD, playing a role in the neurogenic bowel analogous to that of intermittent clean catheterization in bladder treatment.
从意大利的脊髓病治疗单位和康复中心招募了36例神经源性肠道功能障碍（NBD）治疗效果不佳的患者。使用一种新开发的集成系统，配备用于经肛门冲洗的灌肠自控导管（Peristeen，康乐保公司，丹麦科克代尔）进行为期3周的治疗。
评估Peristeen肛门冲洗对NBD及患者生活质量（QoL）的影响。
意大利。
测定所有患者的损伤水平、活动状态和手部功能。使用特定问卷在治疗前后评估NBD症状和QoL。采用McNemar检验和符号检验进行统计分析。
36例患者入组，32例患者完成研究。治疗结束时，28.6%的患者减少或停用了药物。24例患者对护理人员的依赖程度降低。患者对肠道功能的评价（P = 0.001）、QoL评分（P = 0.001）以及对满意度的回答（P = 0.001）均有显著提高。68%的大便失禁患者和63%的便秘患者治疗结果成功。
Peristeen肛门冲洗是一种管理NBD和改善QoL的简单治疗方法。它应被视为NBD的首选治疗方法，在神经源性肠道治疗中发挥的作用类似于间歇性清洁导尿在膀胱治疗中的作用。
