Zhang Wei, Dolan M Eileen
Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Bioinformation. 2008 Jan 11;2(6):238-9. doi: 10.6026/97320630002238.
The International HapMap Project provides a key resource of genotypic data on human lymphoblastoid cell lines derived from four major world populations of European, African, Chinese and Japanese ancestry for researchers to associate with various phenotypic data to find genes affecting health, disease and response to drugs. Recently, the HapMap resource has significantly benefited research areas such as gene expression variation studies. Besides some intrinsic limitations, there are a few challenges that should be considered in the next wave of research using this tremendous resource. We suggest that overcoming these challenges or considering the confounding variables in the interpretation of results can provide more insights into the current views of the human genome as well as complex traits such as drug response variation and susceptibility to common diseases.
国际人类基因组单体型图计划提供了一个关键资源，即关于人类淋巴母细胞系的基因型数据，这些细胞系源自欧洲、非洲、中国和日本血统的四个主要世界人群，供研究人员将其与各种表型数据相关联，以寻找影响健康、疾病和药物反应的基因。最近，人类基因组单体型图资源极大地惠及了基因表达变异研究等研究领域。除了一些内在局限性外，在利用这一巨大资源进行的下一波研究中，还有一些挑战需要考虑。我们建议，克服这些挑战或在结果解释中考虑混杂变量，可以为当前对人类基因组以及诸如药物反应变异和常见疾病易感性等复杂性状的看法提供更多见解。
