Toyoshima M, Sato A, Hayakawa H, Taniguchi M, Imokawa S, Chida K
Department of Internal Medicine, Hamamatsu University School of Medicine.
Intern Med. 1996 Mar;35(3):176-9. doi: 10.2169/internalmedicine.35.176.
We studied the clinical features of minocycline-induced pneumonitis in seven patients. Acute symptoms included fever, dry cough and dyspnea, indicating acute respiratory failure. Diffuse ground glass shadows with Kerley's B lines, bronchial wall thickening, swelling of vascular bundles and pleural effusion were visible on radiography. Bronchoalveolar lavage or transbronchial lung biopsy confirmed pulmonary eosinophilia. Cessation of minocycline led to rapid remission with no treatment or only short-term steroid therapy. The lymphocyte stimulation test for minocycline with peripheral blood lymphocytes was not found to be useful for diagnosis.
我们研究了7例米诺环素诱发肺炎的临床特征。急性症状包括发热、干咳和呼吸困难，提示急性呼吸衰竭。X线检查可见弥漫性磨玻璃影伴Kerley B线、支气管壁增厚、血管束增粗及胸腔积液。支气管肺泡灌洗或经支气管肺活检证实有肺嗜酸性粒细胞增多。停用米诺环素后，无需治疗或仅短期使用类固醇治疗即可迅速缓解。未发现外周血淋巴细胞对米诺环素的淋巴细胞刺激试验对诊断有帮助。
