Chaouloff F
Laboratoire de Pharmacologie, CNRS, CHU Necker, Paris.
Presse Med. 1991 Nov 14;20(37):1817-22.
The aim of this study was to analyse the behaviour effects of tianeptine, an activator of the serotonin neural recapture, in three animal models of depression: immobilization stress, acquired resignation and obligatory swimming. Acute or chronic administration of tianeptine provoked effects comparable to those of the classic antidepressants (tricyclic or atypic). Tianeptine decreased or prevented exploration inhibition induced by immobilization stress, the number of escape failures occurring in a session of adverse and uncontrollable shocks and immobility time following obligatory swimming in a confined space. The relationship between these positive effects of tianeptine and the serotonin system are discussed.
固定应激、习得性无助和强迫游泳。急性或慢性给予噻奈普汀所引发的效应与经典抗抑郁药（三环类或非典型）相当。噻奈普汀减少或防止了由固定应激诱导的探索抑制、在一组不良且不可控电击期间出现的逃避失败次数以及在密闭空间中强迫游泳后的不动时间。文中讨论了噻奈普汀的这些积极效应与血清素系统之间的关系。
