Nakagawa Takahiko, Cirillo Pietro, Sato Waichi, Gersch Michael, Sautin Yuri, Roncal Carlos, Mu Wei, Sánchez-Lozada L Gabriela, Johnson Richard J
Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL, 32610, USA,
Intern Emerg Med. 2008 Dec;3(4):313-8. doi: 10.1007/s11739-008-0141-3. Epub 2008 Mar 5.
The level of serum uric acid in human has been increasing over the last decades, and correlates with an increase prevalence of renal disease and metabolic syndrome. Understanding the role of uric acid in these conditions may provide clues for preventing the current epidemic of renal disease. Controversy still remains if hyperuricemia is simply a consequence or a cause of renal disease although epidemiological studies have attempted to resolve this issue. In this review, we discuss the clinical and experimental evidence for a causal role of hyperuricemia in renal diseases and potential relationships of hyperuricemia with metabolic syndrome.
在过去几十年里，人类血清尿酸水平一直在上升，且与肾脏疾病和代谢综合征患病率的增加相关。了解尿酸在这些病症中的作用可能为预防当前的肾脏疾病流行提供线索。尽管流行病学研究试图解决这个问题，但高尿酸血症究竟只是肾脏疾病的一个后果还是病因仍存在争议。在这篇综述中，我们讨论了高尿酸血症在肾脏疾病中因果作用的临床和实验证据，以及高尿酸血症与代谢综合征之间的潜在关系。
