School of Medical Laboratory Sciences, Institute of Health Sciences, Jimma University, P.O. Box 378, Jimma, Ethiopia.
Hawasa University, Hawassa, Ethiopia.
BMC Endocr Disord. 2017 Dec 12;17(1):76. doi: 10.1186/s12902-017-0226-y.
Metabolic syndrome is a cluster of the most dangerous heart attack risk factors such as diabetes and prediabetes, abdominal obesity, high cholesterol and high blood pressure. Hyperuricemia is a condition in which the serum uric acid concentration is greater than 5.5 mg per deciliter for child and greater than 7.2 and 6.0 mg per deciliters for male and female adults respectively.
A cross-sectional study was conducted to determine the magnitude of hyperuricemia and associated factors among type 2 diabetes mellitus patients at Hawassa Comprehensive Specialized Hospital (HCSH) from February 28 to May 30 /2017. A random sampling technique was used to include 319 study subjects and a signed consent had been provided by each study subject before running any data collection. An interviewer administered structured questionnaire was used to collect socio-demographic and some clinically useful data. In addition to this, we reviewed the records of the study subjects to obtain other useful clinical data. Five milliliter blood specimen was collected from each study subjects after overnight fasting. A25TM Bio-System Random Access chemistry analyzer was used for blood sample analysis. All data were checked visually, coded and entered into epi-data version 3.4 and statistical analysis was performed using SPSS version 20.0 software. Bi-variate and multivariate logistic regressions were used to determine the association between explanatory and the outcome variables.
The prevalence of hyperuricemia and metabolic syndrome among type 2 diabetic patients in the study area were 33.8%(n = 106) and 70.1% (n = 220) respectively. Having age greater or equal to 45 years (AOR: 1.9, CI: 1.-3.2, P value =0.015) and having metabolic syndrome (AOR: 2.6, CI: 1.5-4.7, P value = 0.001) were the determinant variables for hyperuricemia among type 2 diabetic patients.
There was high prevalence of hyperuricemia among type 2 diabetic patients with high prevalence of metabolic syndrome. Therefore, regular health information about life style modification, early diagnosis and treatment for hyperuricemia and metabolic syndrome are essential to reduce hyperuricemia and metabolic syndrome in type 2 diabetic patients.
代谢综合征是一组最危险的心脏病发作风险因素，如糖尿病和前驱糖尿病、腹部肥胖、高胆固醇和高血压。高尿酸血症是一种血清尿酸浓度大于 5.5mg/dL 的情况，对于儿童而言，分别为大于 7.2 和 6.0mg/dL 对于男性和女性成年人。
本横断面研究旨在确定 2017 年 2 月 28 日至 5 月 30 日在 Hawassa 综合专科医院（HCSH）的 2 型糖尿病患者中高尿酸血症的严重程度及其相关因素。采用随机抽样技术纳入 319 名研究对象，在进行任何数据收集之前，每位研究对象均签署了同意书。采用访谈者管理的结构化问卷收集社会人口统计学和一些临床有用数据。除此之外，我们还查阅了研究对象的记录以获得其他有用的临床数据。采集每位研究对象的 5 毫升空腹血样。使用 A25TM Bio-System 随机访问化学分析仪进行血液样本分析。所有数据均进行了肉眼检查、编码并录入 epi-data 版本 3.4，使用 SPSS 版本 20.0 软件进行统计分析。采用双变量和多变量逻辑回归来确定解释变量和结果变量之间的关联。
在所研究的地区，2 型糖尿病患者中高尿酸血症和代谢综合征的患病率分别为 33.8%（n=106）和 70.1%（n=220）。年龄大于或等于 45 岁（AOR：1.9，CI：1.0-3.2，P 值=0.015）和患有代谢综合征（AOR：2.6，CI：1.5-4.7，P 值=0.001）是 2 型糖尿病患者高尿酸血症的决定因素。
2 型糖尿病患者中高尿酸血症的患病率较高，且代谢综合征的患病率也较高。因此，定期提供关于生活方式改变的健康信息、早期诊断和治疗高尿酸血症和代谢综合征对于降低 2 型糖尿病患者的高尿酸血症和代谢综合征至关重要。
