糖尿病大鼠糖原诱导的腹腔细胞产生细胞因子减少。
Reduced cytokine production by glycogen-elicited peritoneal cells from diabetic rats.
作者信息
Alba-Loureiro Tatiana Carolina, Pithon-Curi Tania Cristina, Curi Rui
机构信息
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Brazil.
出版信息
Shock. 2008 Sep;30(3):308-10. doi: 10.1097/SHK.0b013e318164e834.
IL-1beta, TNF-alpha, cytokine-induced neutrophil chemoattractant-2alpha/beta, and IL-10 measurements were performed in elicited peritoneal cells from control, diabetic, and insulin-treated diabetic rats. Production/liberation of these cytokines was decreased in elicited peritoneal cells from diabetic rats. These changes were abolished by insulin treatment of diabetic rats. The alterations observed might be involved in the impaired inflammatory response and high occurrence of apoptosis observed in neutrophils under diabetic states.
在对照大鼠、糖尿病大鼠以及胰岛素治疗的糖尿病大鼠的诱导腹膜细胞中进行了白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、细胞因子诱导的中性粒细胞趋化因子-2α/β（CINC-2α/β）和白细胞介素-10（IL-10）的检测。糖尿病大鼠诱导腹膜细胞中这些细胞因子的产生/释放减少。糖尿病大鼠经胰岛素治疗后，这些变化消失。观察到的改变可能与糖尿病状态下中性粒细胞炎症反应受损和凋亡发生率高有关。
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