Hatcher H, Planalp R, Cho J, Torti F M, Torti S V
Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Cell Mol Life Sci. 2008 Jun;65(11):1631-52. doi: 10.1007/s00018-008-7452-4.
Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. The pleiotropic activities of curcumin derive from its complex chemistry as well as its ability to influence multiple signaling pathways, including survival pathways such as those regulated by NF-kappaB, Akt, and growth factors; cytoprotective pathways dependent on Nrf2; and metastatic and angiogenic pathways. Curcumin is a free radical scavenger and hydrogen donor, and exhibits both pro- and antioxidant activity. It also binds metals, particularly iron and copper, and can function as an iron chelator. Curcumin is remarkably non-toxic and exhibits limited bioavailability. Curcumin exhibits great promise as a therapeutic agent, and is currently in human clinical trials for a variety of conditions, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis and Alzheimer's disease.
姜黄素是传统草药疗法和膳食香料姜黄（Curcuma longa）中的活性成分。姜黄素具有一系列惊人的有益特性，包括抗炎、抗氧化、化学预防和化学治疗活性。姜黄素的多效性活性源于其复杂的化学性质以及影响多种信号通路的能力，这些信号通路包括生存通路，如由核因子κB、Akt和生长因子调节的通路；依赖于Nrf2的细胞保护通路；以及转移和血管生成通路。姜黄素是一种自由基清除剂和氢供体，兼具促氧化和抗氧化活性。它还能结合金属，特别是铁和铜，并可作为铁螯合剂发挥作用。姜黄素具有显著的低毒性且生物利用度有限。姜黄素作为一种治疗剂具有很大的前景，目前正处于针对多种病症的人体临床试验中，这些病症包括多发性骨髓瘤、胰腺癌、骨髓增生异常综合征、结肠癌、银屑病和阿尔茨海默病。
