Institute of Biomolecular Chemistry of CNR, Padua Unit, via F. Marzolo 1, Padua, Italy.
Curr Med Chem. 2014;21(2):204-22. doi: 10.2174/092986732102131206115810.
Curcumin is the major yellow pigment extracted from turmeric, a commonly used spice in Asian cuisine and extensively employed in ayurvedic herbal remedies. A number of studies have shown that curcumin can be a prevention and a chemotherapeutic agent for colon, skin, oral and intestinal cancers. Curcumin is also well known for its antiinflammatory and antioxidant properties, showing high reactivity towards peroxyl radicals, and thus acting as a free radical scavenger. Recently, experimental studies have demonstrated that curcumin might be used in the prevention and the cure of Alzheimer's disease. Indeed, curcumin injected peripherally in vivo into aged Tg mice crossed the blood-brain barrier and bound to amyloid plaques, reducing amyloid levels and plaque formation decisively. The present review will resume the most recent developments in the medicinal chemistry of curcumin and curcumin-like molecules.
姜黄素是从姜黄中提取的主要黄色素，姜黄是亚洲菜肴中常用的香料，在印度草医学草药疗法中也广泛使用。许多研究表明，姜黄素可以预防和治疗结肠癌、皮肤癌、口腔癌和肠癌。姜黄素还因其抗炎和抗氧化特性而闻名，它对过氧自由基具有很高的反应活性，因此可以作为自由基清除剂。最近的实验研究表明，姜黄素可能用于预防和治疗阿尔茨海默病。事实上，姜黄素经体内外周注射到老年 Tg 小鼠体内，穿过血脑屏障并与淀粉样斑块结合，显著降低了淀粉样蛋白水平和斑块形成。本综述将总结姜黄素和姜黄素类似物的药物化学的最新进展。
