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Interferon-beta therapy for malignant melanoma: the dose is crucial for inhibition of proliferation and induction of apoptosis of melanoma cells.

作者信息

Kubo Hitomi, Ashida Atsuko, Matsumoto Kazuhiko, Kageshita Toshiro, Yamamoto Akifumi, Saida Toshiaki

机构信息

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

出版信息

Arch Dermatol Res. 2008 Jul;300(6):297-301. doi: 10.1007/s00403-008-0841-6. Epub 2008 Mar 7.

DOI:10.1007/s00403-008-0841-6
PMID:18324409
Abstract

We investigated the anti-tumor effect of human interferon-beta (HuIFN-beta) against malignant melanoma. In vitro study revealed that HuIFN-beta not only inhibited proliferation of melanoma cells (seven cell lines: MM-AN, MM-BP, MM-LH, MM-RU, PM-WK, RPM-EP, RPM-MC) but also induced apoptosis in a dose dependent fashion, though the sensitivity to HuIFN-beta was different among cell lines. In addition, we administered HuIFN-beta into cutaneous metastatic lesions of melanoma and evaluated clinical and histopathological effects. Although the size of the metastatic cutaneous lesion did not change by the intralesional injection of HuIFN-beta, histopathological examination revealed apoptotic changes of melanoma cells along with dense lymphohistiocytic infiltration. The present study confirmed direct and indirect inhibitory effects of HuIFN-beta on human melanoma cells and suggests that local higher concentration of HuIFN-beta is needed to eradicate melanoma lesions.

摘要

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