Rodondi Nicolas, Auer Reto, Devine Patrick J, O'Malley Patrick G, Hayoz Daniel, Cornuz Jacques
Department of Ambulatory Care and Community Medicine, University of Lausanne, Switzerland.
Nicotine Tob Res. 2008 Mar;10(3):541-6. doi: 10.1080/14622200801902011.
Showing smokers their own atherosclerotic plaques might increase motivation for smoking cessation, since they underestimate their own risk for smoking-related diseases. To assess the feasibility and optimal processes of studying the impact of carotid atherosclerotic plaque screening in smokers, we enrolled 30 daily cigarette smokers, aged 40-70 years, in an observational pre-post pilot study. All smokers underwent smoking cessation counseling, nicotine replacement therapy, a carotid ultrasound, an educational tutorial on atherosclerosis, baseline and 2-month motivation to change assessment, and assessment of smoking cessation at 2 months. Participants had a mean smoking duration of 34 years (SD = 7). Carotid plaques were present in 22 smokers (73%). Between baseline and 2 months after plaque screening, motivation for smoking cessation increased from 7.4 to 8.4 out of 10 (p = .02), particularly in those with plaques (7.2 to 8.7, p = .008). At 2 months, the smoking quit rate was 63%, with a quit rate of 73% in those with plaques vs. 38% in those without plaques (p = .10). Perceived stress, anxiety, and depression did not increase after screening. 96% of respondents answered correctly at least 80% of questions regarding atherosclerosis knowledge at baseline and after 2 months. In conclusion, studying the process of screening for carotid plaques for the purpose of increasing motivation for smoking cessation, in addition to counseling and drug therapy for smoking cessation in long-term smokers, appears feasible. The impact of carotid plaque screening on smoking cessation should be examined in larger randomized controlled trials with sufficient power to assess the impact on long-term smoking cessation rates.
向吸烟者展示他们自身的动脉粥样硬化斑块可能会增加戒烟的动力,因为他们低估了自己患吸烟相关疾病的风险。为了评估研究颈动脉粥样硬化斑块筛查对吸烟者影响的可行性和最佳流程,我们招募了30名年龄在40 - 70岁之间的每日吸烟者,进行一项观察性前后对照试点研究。所有吸烟者均接受了戒烟咨询、尼古丁替代疗法、颈动脉超声检查、关于动脉粥样硬化的教育教程、基线及2个月时的戒烟动机评估,以及2个月时的戒烟情况评估。参与者的平均吸烟时长为34年(标准差 = 7)。22名吸烟者(73%)存在颈动脉斑块。在斑块筛查的基线期和2个月后,戒烟动机从10分制中的7.4分提高到了8.4分(p = 0.02),尤其是那些有斑块的吸烟者(从7.2分提高到8.7分,p = 0.008)。在2个月时,戒烟率为63%,有斑块者的戒烟率为73%,无斑块者为38%(p = 0.10)。筛查后感知到的压力、焦虑和抑郁并未增加。96%的受访者在基线期和2个月后关于动脉粥样硬化知识的问题中至少80%回答正确。总之,为增加戒烟动力而研究颈动脉斑块筛查流程,除了对长期吸烟者进行戒烟咨询和药物治疗外,似乎是可行的。颈动脉斑块筛查对戒烟的影响应在有足够能力评估对长期戒烟率影响的更大规模随机对照试验中进行检验。