Eadie Mervyn J
University of Queensland, and Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia 4029, Australia.
Expert Opin Drug Saf. 2008 Mar;7(2):195-209. doi: 10.1517/14740338.7.2.195.
There is still uncertainty concerning the risk of fetal malformation associated with the intake of various individual antiepileptic drugs in pregnant women.
To assess the better-quality available evidence concerning the fetal hazards from exposure to antiepileptic drug monotherapy during human pregnancy.
Examination of the available English language literature, particularly that dealing with individual antiepileptic drugs used in monotherapy, in the larger case series with better-quality internal comparison data.
There is reasonable evidence that valproate is a significant teratogen during therapeutic use in women; the other older antiepileptic drugs (phenobarbitone, phenytoin, carbamazepine) probably have some teratogenic potential, but less than valproate; the situation regarding the more recently marketed antiepileptic drugs is not yet clear.
孕妇服用各种不同的抗癫痫药物与胎儿畸形风险之间仍存在不确定性。
评估关于人类孕期暴露于抗癫痫药物单药治疗对胎儿危害的质量更高的现有证据。
查阅现有的英文文献，特别是那些涉及单药治疗中使用的个别抗癫痫药物、具有质量更高的内部对照数据的较大病例系列。
有合理证据表明丙戊酸盐在女性治疗使用期间是一种重要的致畸剂；其他较老的抗癫痫药物（苯巴比妥、苯妥英、卡马西平）可能有一定致畸潜力，但低于丙戊酸盐；关于最近上市的抗癫痫药物的情况尚不清楚。
