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本文引用的文献

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Language skills of school-aged children prenatally exposed to antiepileptic drugs.产前暴露于抗癫痫药物的学龄儿童的语言技能。
Neurology. 2011 Feb 22;76(8):719-26. doi: 10.1212/WNL.0b013e31820d62c7.
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Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study.子宫内暴露于卡马西平与特定先天性畸形：系统评价与病例对照研究。
BMJ. 2010 Dec 2;341:c6581. doi: 10.1136/bmj.c6581.
3
Long-term developmental outcome of children of women with epilepsy, unexposed or exposed prenatally to antiepileptic drugs: a meta-analysis of cohort studies.抗癫痫药物暴露或未暴露于抗癫痫药物的女性所生孩子的长期发育结局：队列研究的荟萃分析。
Drug Saf. 2010 Jan 1;33(1):73-9. doi: 10.2165/11317640-000000000-00000.
4
A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy.一项前瞻性研究，探讨宫内暴露于卡马西平、拉莫三嗪或丙戊酸钠单药治疗的儿童的认知流畅性和原创性。
Epilepsy Behav. 2009 Dec;16(4):609-16. doi: 10.1016/j.yebeh.2009.09.024. Epub 2009 Nov 4.
5
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.胎儿暴露于抗癫痫药物后3岁时的认知功能。
N Engl J Med. 2009 Apr 16;360(16):1597-605. doi: 10.1056/NEJMoa0803531.
6
Epileptic disorders in pregnancy: an overview.妊娠期癫痫疾病概述
Curr Opin Obstet Gynecol. 2008 Dec;20(6):557-62. doi: 10.1097/GCO.0b013e3283184059.
7
Antiepileptic drugs as human teratogens.作为人类致畸剂的抗癫痫药物。
Expert Opin Drug Saf. 2008 Mar;7(2):195-209. doi: 10.1517/14740338.7.2.195.
8
Patient page. Risk of fetal death and malformation related to seizure medications.患者页面。与抗癫痫药物相关的胎儿死亡和畸形风险。
Neurology. 2006 Aug 8;67(3):E6-7. doi: 10.1212/01.wnl.0000233835.05212.5d.
9
Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register.孕期抗癫痫药物的致畸风险：来自英国癫痫与妊娠登记处的一项前瞻性研究。
J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):193-8. doi: 10.1136/jnnp.2005.074203. Epub 2005 Sep 12.
10
Major malformations in offspring of women with epilepsy.癫痫女性后代中的严重畸形。
Neurology. 2003 Feb 25;60(4):575-9. doi: 10.1212/01.wnl.0000044157.28073.dc.

卡马西平在妊娠期服用安全吗？

Is carbamazepine safe to take during pregnancy?

出版信息

Can Fam Physician. 2012 Feb;58(2):163-4.

PMID:22337738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3279268/
Abstract

QUESTION

Some of my pregnant patients are afraid to take their antiepileptic drugs during pregnancy because of the known risk of malformations and the neurodevelopmental problems associated with valproic acid. Are there similar concerns with carbamazepine?

ANSWER

Similar to valproic acid, carbamazepine increases the risk of neural tube defects; however, it does not increase the risk of other malformations. Carbamazepine is also not associated with an increased risk of developmental delay.

摘要

问题

我的一些孕妇患者因为已知的畸形风险以及与丙戊酸相关的神经发育问题而害怕在怀孕期间服用抗癫痫药物。卡马西平是否存在类似的担忧？

答案

与丙戊酸类似，卡马西平增加神经管缺陷的风险；然而，它不会增加其他畸形的风险。卡马西平也与发育迟缓风险的增加无关。