Division of Immunology, Children's Hospital, Harvard Medical School, Boston, MA, USA.
Immunol Rev. 2011 Jul;242(1):128-43. doi: 10.1111/j.1600-065X.2011.01024.x.
Immunoglobulin E (IgE) antibodies have long been recognized as the antigen-specific triggers of allergic reactions. This review briefly introduces the established functions of IgE in immediate hypersensitivity and then focuses on emerging evidence from our own investigations as well as those of others that IgE plays important roles in protective immunity against parasites and exerts regulatory influences in the expression of its own receptors, FcεRI and CD23, as well as controlling mast cell homeostasis. We provide an overview of the multifaceted ways in which IgE antibodies contribute to the pathology of food allergy and speculate regarding potential mechanisms of action of IgE blockade.
免疫球蛋白 E(IgE)抗体长期以来一直被认为是过敏反应的抗原特异性触发物。这篇综述简要介绍了 IgE 在即刻超敏反应中的既定功能,然后重点介绍了我们自己和其他人的研究中的新证据,表明 IgE 在对抗寄生虫的保护性免疫中发挥重要作用,并对其自身受体 FcεRI 和 CD23 的表达以及控制肥大细胞动态平衡产生调节影响。我们概述了 IgE 抗体导致食物过敏发病机制的多方面方式,并推测了 IgE 阻断的潜在作用机制。