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完全植入式中心静脉通路装置插入术后发生坏疽性脓皮病。

Pyoderma gangrenosum after totally implanted central venous access device insertion.

作者信息

Inan Ihsan, Myers Patrick O, Braun Rolf, Hagen Monica E, Morel Philippe

机构信息

Visceral Surgery Unit, Department of Surgery, Geneva University Hospital, Rue Micheli-du-Crest 24, CH-1211 Geneva, Switzerland.

出版信息

World J Surg Oncol. 2008 Mar 6;6:31. doi: 10.1186/1477-7819-6-31.

Abstract

BACKGROUND

Pyoderma gangrenosum is an aseptic skin disease. The ulcerative form of pyoderma gangrenosum is characterized by a rapidly progressing painful irregular and undermined bordered necrotic ulcer. The aetiology of pyoderma gangrenosum remains unclear. In about 70% of cases, it is associated with a systemic disorder, most often inflammatory bowel disease, haematological disease or arthritis. In 25-50% of cases, a triggering factor such as recent surgery or trauma is identified. Treatment consists of local and systemic approaches. Systemic steroids are generally used first. If the lesions are refractory, steroids are combined with other immunosuppressive therapy or to antimicrobial agents.

CASE PRESENTATION

A 90 years old patient with myelodysplastic syndrome, seeking regular transfusions required totally implanted central venous access device (Port-a-Cath(R)) insertion. Fever and inflammatory skin reaction at the site of insertion developed on the seventh post-operative day, requiring the device's explanation. A rapid progression of the skin lesions evolved into a circular skin necrosis. Intravenous steroid treatment stopped the necrosis' progression.

CONCLUSION

Early diagnosis remains the most important step to the successful treatment of pyoderma gangrenosum.

摘要

背景

坏疽性脓皮病是一种无菌性皮肤病。坏疽性脓皮病的溃疡性形式的特征是迅速进展的疼痛性、不规则且边缘呈潜行性的坏死性溃疡。坏疽性脓皮病的病因仍不清楚。在约70%的病例中,它与一种全身性疾病相关,最常见的是炎症性肠病、血液系统疾病或关节炎。在25% - 50%的病例中,可确定有触发因素,如近期手术或创伤。治疗包括局部和全身治疗方法。通常首先使用全身性类固醇。如果病变难治,类固醇会与其他免疫抑制疗法或抗菌药物联合使用。

病例介绍

一名90岁患有骨髓增生异常综合征的患者,因寻求定期输血需要植入完全植入式中心静脉通路装置(Port-a-Cath(R))。术后第7天在插入部位出现发热和炎症性皮肤反应,需要移除该装置。皮肤病变迅速进展,演变成圆形皮肤坏死。静脉注射类固醇治疗阻止了坏死的进展。

结论

早期诊断仍然是成功治疗坏疽性脓皮病的最重要步骤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3f5/2270824/2a8c20e66c64/1477-7819-6-31-1.jpg

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