Department of Pharmacology, M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana-133207, India.
Department of Pharmacy, Chaudhary Bansilal University, Bhiwani, India.
Curr Drug Targets. 2024;25(4):221-240. doi: 10.2174/0113894501280331240213063333.
Carpal tunnel syndrome (CTS) is a condition that is caused by medial nerve compression, resulting in symptoms such as numbness, tightness, or weakness in the hand.
The aim of the study was to find out the genetic modulation, mechanism, available treatment, and recommendation for carpal tunnel syndrome at its specific stage.
Almost 200 papers were searched for this review article, and 145 articles were selected. The literature was collected from different sources like Google scholar, PubMed, a directory of open-access journals, and science.gov by using keywords, such as treatment, risk factors, recommendation, and clinical features of carpal tunnel syndrome.
The most efficient non-surgical treatment is methylprednisolone acetate, which reduces inflammation by acting on the glucocorticoid receptor in conjunction with immunofilling. It has also been used successfully as a second-line drug for the treatment of patients with mild or moderate conditions in order to provide relief. New non-pharmacological options include laser therapy in acupuncture, transcutaneous electric nerve stimulation (TENS), and sham therapy. Modern treatments like TENS, laser therapy, splints, and injections of methylprednisolone acetate have been demonstrated to be helpful in sporadic situations. For patients with mild and moderate problems, more research should be conducted that includes the combination of these surgical and non-surgical treatments.
We propose a multifunctional panel construct and define standard data items for future research into carpal tunnel syndrome. A discussion on idiopathic carpal tunnel syndrome, risk factors, combination of therapies, using guidelines-based recommendations and treatment should be initiated.
腕管综合征（CTS）是一种由正中神经受压引起的疾病，导致手部出现麻木、紧绷或无力等症状。
本研究旨在探讨腕管综合征在特定阶段的遗传调控、发病机制、现有治疗方法和推荐意见。
本综述文章共检索了近 200 篇论文，最终选择了 145 篇。文献资料来自 Google Scholar、PubMed、开放获取期刊目录和 science.gov 等不同来源，使用的关键词包括治疗、风险因素、推荐意见和腕管综合征的临床特征等。
最有效的非手术治疗方法是醋酸甲泼尼龙，它通过与糖皮质激素受体结合发挥作用，从而减轻炎症。它也已成功用作轻度或中度患者的二线药物，以提供缓解。新的非药物选择包括针灸中的激光治疗、经皮神经电刺激（TENS）和假治疗。TENS、激光治疗、夹板和醋酸甲泼尼龙注射等现代治疗方法已被证明对偶发性病例有效。对于轻度和中度问题的患者，应进行更多包括这些手术和非手术治疗相结合的研究。
我们提出了一个多功能面板结构，并为未来的腕管综合征研究定义了标准数据项。应启动对特发性腕管综合征、风险因素、联合治疗、使用基于指南的推荐意见和治疗的讨论。
