Cowper Shawn E, Rabach Morgan, Girardi Michael
Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520-8059, USA.
Eur J Radiol. 2008 May;66(2):191-9. doi: 10.1016/j.ejrad.2008.01.016. Epub 2008 Mar 5.
Nephrogenic systemic fibrosis (NSF) is a relative newcomer to the world of medicine. NSF was introduced just over 10 years ago as nephrogenic fibrosing dermopathy, but with further investigation, its systemic nature was determined. The strict adherence to a definition requiring both clinical and pathological concordance has allowed for careful separation of this entity from other fibrosing disorders, leading eventually to the realization that gadolinium-based contrast agents were closely associated with its onset. As planned prospective studies get underway, it is of paramount importance that researchers and clinicians realize that NSF remains a very challenging diagnosis, and that both clinical and histopathological criteria must be employed to reach the most accurate diagnosis possible.
肾源性系统性纤维化（NSF）在医学界是一个相对较新的病症。NSF在10多年前刚被提出时称为肾源性纤维化皮肤病，但随着进一步研究，其全身性特征得以确定。严格遵循临床和病理一致性的定义，使得该病症能与其他纤维化疾病仔细区分开来，最终发现基于钆的造影剂与其发病密切相关。随着计划中的前瞻性研究的开展，研究人员和临床医生必须认识到NSF仍然是一个极具挑战性的诊断，必须采用临床和组织病理学标准以尽可能做出最准确的诊断，这至关重要。
