de Soet J J, Laine M L
Afdeling Parodontologie, sectie Orale Microbiologie, van het Academisch Centrum Tandheelkunde Amsterdam (ACTA).
Ned Tijdschr Tandheelkd. 2008 Feb;115(2):78-82.
Caries is a multi-factorial disease, primarily caused by acids. Acids are produced by bacteria which ferment sugar. The aetiology and progress of caries are influenced by life-style and environmental factors, as well as congenital components. Based on, among other things, research concerning twins, the literature suggests that there are hereditary components of caries and life-style and environmental components. With the unravelling of the human genome, it is more easy to study individual genes in relation to the caries process. Because of its multifactorial nature, one has to realise that there is only a beginning of understanding the caries processes at molecular level.
龋齿是一种多因素疾病，主要由酸引起。酸由发酵糖的细菌产生。龋齿的病因和发展受到生活方式、环境因素以及先天性因素的影响。基于对双胞胎等的研究，文献表明龋齿存在遗传因素以及生活方式和环境因素。随着人类基因组的解密，研究与龋齿过程相关的单个基因变得更加容易。由于其多因素性质，人们必须认识到在分子水平上对龋齿过程的理解才刚刚开始。
