Bretz Walter A, Corby Patricia M A, Melo Mário R, Coelho Mânia Q, Costa Simone M, Robinson Miguel, Schork Nicholas J, Drewnowski Adam, Hart Thomas C
College of Dentistry, New York University, 345 East 24th St., New York, NY 10010, USA.
Arch Oral Biol. 2006 Dec;51(12):1156-60. doi: 10.1016/j.archoralbio.2006.06.003. Epub 2006 Aug 28.
The aim of this study was to determine heritability estimates for dental caries traits and sucrose sweetness preference.
Participants included 115 pairs of twins 4-7-years-old. Caries exams followed NIDCR criteria where the severity of the lesion was also determined. Twins ranked their preference for five concentrations of sucrose/grape juice solutions (0.15-1.17M) with a Face Scale. Variables submitted to analysis: (1) surface-based caries prevalence rate (SBCPR); (2) lesion severity index (LSI); (3) sucrose sweetness preference score (SSPS). Heritability analyses were performed with the SOLAR software package.
Heritability estimates adjusted for age and gender were: SBCPR-h(2)=64.6 (p<.00001), LSI-h(2)=61.7 (p<.00001) and SSPS-h(2)=55.2 (p<.00001). Treating SPSS as a covariate in the SBCPR and LSI models did not alter heritability estimates.
These results suggest that variation in dental caries traits and sucrose sweetness preference have a significant genetic contribution that is mediated independently.
本研究旨在确定龋齿特征和蔗糖甜度偏好的遗传力估计值。
研究对象包括115对4至7岁的双胞胎。龋齿检查遵循美国国立牙科和颅面研究所（NIDCR）的标准，同时确定病变的严重程度。双胞胎使用面部量表对五种浓度的蔗糖/葡萄汁溶液（0.15 - 1.17M）的甜度偏好进行排序。纳入分析的变量有：（1）基于表面的龋齿患病率（SBCPR）；（2）病变严重程度指数（LSI）；（3）蔗糖甜度偏好评分（SSPS）。使用SOLAR软件包进行遗传力分析。
经年龄和性别调整后的遗传力估计值为：SBCPR - h(2)=64.6（p <.00001），LSI - h(2)=61.7（p <.00001），SSPS - h(2)=55.2（p <.00001）。在SBCPR和LSI模型中将SPSS作为协变量处理并未改变遗传力估计值。
这些结果表明，龋齿特征和蔗糖甜度偏好的变异具有显著的独立介导的遗传贡献。
