Opal S, Garg S, Jain J, Walia I
Department of Pediatric and Preventive Dentistry, BRS Dental College, Panchkula, Haryana, India.
Aust Dent J. 2015 Mar;60(1):2-11. doi: 10.1111/adj.12262.
This article reviews the literature on genetic aspects of dental caries and provides a framework for the rapidly changing disease model of caries. The scope is genetic aspects of various dental factors affecting dental caries. The PubMed database was searched for articles with keywords 'caries', 'genetics', 'taste', 'diet' and 'twins'. This was followed by extensive handsearching using reference lists from relevant articles. The post-genomic era will present many opportunities for improvement in oral health care but will also present a multitude of challenges. We can conclude from the literature that genes have a role to play in dental caries; however, both environmental and genetic factors have been implicated in the aetiology of caries. Additional studies will have to be conducted to replicate the findings in a different population. Identification of genetic risk factors will help screen and identify susceptible patients to better understand the contribution of genes in caries aetiopathogenesis. Information derived from these diverse studies will provide new tools to target individuals and/or populations for a more efficient and effective implementation of newer preventive measures and diagnostic and novel therapeutic approaches in the management of this disease.
本文回顾了关于龋齿遗传方面的文献，并为快速变化的龋齿疾病模型提供了一个框架。范围是影响龋齿的各种牙齿因素的遗传方面。在PubMed数据库中搜索了关键词为“龋齿”“遗传学”“味觉”“饮食”和“双胞胎”的文章。随后，利用相关文章的参考文献列表进行了广泛的手工检索。后基因组时代将为口腔保健的改善带来许多机遇，但也将带来众多挑战。我们可以从文献中得出结论，基因在龋齿中发挥作用；然而，环境和遗传因素都与龋齿的病因有关。必须进行更多研究以在不同人群中重复这些发现。识别遗传风险因素将有助于筛查和识别易感患者，以更好地理解基因在龋齿发病机制中的作用。从这些不同研究中获得的信息将提供新工具，以针对个体和/或人群，更高效、有效地实施新的预防措施以及诊断和新型治疗方法来管理这种疾病。
