Enomoto Shotaro, Oka Masashi, Ohata Hiroshi, Mukoubayashi Chizu, Watanabe Mika, Moribata Kosaku, Muraki Yosuke, Shingaki Naoki, Deguchi Hisanobu, Ueda Kazuki, Inoue Izumi, Maekita Takao, Iguchi Mikitaka, Yanaoka Kimihiko, Tamai Hideyuki, Fujishiro Mitsuhiro, Mohara Osamu, Ichinose Masao
Shotaro Enomoto, Masashi Oka, Chizu Mukoubayashi, Mika Watanabe, Kosaku Moribata, Yosuke Muraki, Naoki Shingaki, Hisanobu Deguchi, Kazuki Ueda, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Kimihiko Yanaoka, Hideyuki Tamai, Masao Ichinose, Second Department of Internal Medicine, Wakayama Medical University, Wakayama 641-0012, Japan.
World J Gastrointest Endosc. 2011 Apr 16;3(4):71-7. doi: 10.4253/wjge.v3.i4.71.
To evaluate the association of Helicobacter pylori (H.pylori)-related chronic gastritis stage with upper gastrointestinal symptoms and gastroesophageal reflux disease (GERD).
Subjects underwent upper gastrointestinal endoscopy, a questionnaire using a frequency scale for symptoms of GERD (FSSG), and measurements of serum H.pylori-antibody and pepsinogen (PG) levels. They were classified into the following 4 groups in terms of H.pylori-related chronic gastritis stage: Group A (n = 219), H.pylori(-)PG(-); Group B (n = 310), H.pylori(+)PG(-); Group C (n = 279), H.pylori(+)PG(+); and Group D (n = 17), H.pylori(-)PG(+).
Reflux esophagitis occurred in 30.6% of Group A, 14.5% of Group B, 6.8% of Group C, and 0% of Group D (P < 0.001). Scores for acid reflux symptoms decreased significantly with chronic gastritis stage (from Group A to D) (P < 0.05), while scores for dysmotility symptoms did not differ significantly. The prevalence of non-erosive reflux disease (NERD) did not differ among groups. However, in subjects with GERD, the prevalence of NERD tended to increase with chronic gastritis stage (P = 0.081).
Acid reflux symptoms and the prevalence of reflux esophagitis can be assessed by measuring both serum H.pylori-antibody and PG levels.
评估幽门螺杆菌（H.pylori）相关性慢性胃炎分期与上消化道症状及胃食管反流病（GERD）之间的关联。
研究对象接受了上消化道内镜检查、使用胃食管反流病症状频率量表（FSSG）的问卷调查以及血清幽门螺杆菌抗体和胃蛋白酶原（PG）水平的测定。根据幽门螺杆菌相关性慢性胃炎分期，他们被分为以下4组：A组（n = 219），幽门螺杆菌（-）胃蛋白酶原（-）；B组（n = 310），幽门螺杆菌（+）胃蛋白酶原（-）；C组（n = 279），幽门螺杆菌（+）胃蛋白酶原（+）；D组（n = 17），幽门螺杆菌（-）胃蛋白酶原（+）。
A组中反流性食管炎的发生率为30.6%，B组为14.5%，C组为6.8%，D组为0%（P < 0.001）。随着慢性胃炎分期（从A组到D组），酸反流症状评分显著降低（P < 0.05），而运动障碍症状评分无显著差异。各组中非糜烂性反流病（NERD）的患病率无差异。然而，在患有GERD的受试者中，NERD的患病率倾向于随着慢性胃炎分期增加（P = 0.081）。
通过同时检测血清幽门螺杆菌抗体和胃蛋白酶原水平，可以评估酸反流症状及反流性食管炎的患病率。
