代谢组学揭示了肉苁蓉在氢化可的松诱导的“肾虚综合征”动物模型中的治疗作用。
Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'.
机构信息
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Chin Med. 2008 Mar 10;3:3. doi: 10.1186/1749-8546-3-3.
BACKGROUND
Herba Cistanches (Roucongrong) is effective in treating Shenxu Zheng ('kidney-deficiency syndrome'). However, the mechanisms and systemic metabolic responses to the herbal intervention are unclear.
METHODS
Using GC-MS-based metabolic profiling, we investigated the metabolic responses to Herba Cistanches intervention in a rat model of the hydrocortisone-induced 'kidney-deficiency syndrome'.
RESULTS
The metabolic profiles of the rats after hydrocortisone injection deviated from the pre-dose metabolic state at different time points, ranging from day 1 to day 10, whereas the metabolic profiles of the rats treated with both hydrocortisone and water extract of Herba Cistanches returned to the pre-dose state on day 10.
CONCLUSION
The intervention of Herba Cistanches caused a systemic recovery from the hydrocortisone-induced metabolic perturbation in rats. This study also demonstrates that metabolic profiling is useful in studying therapeutic mechanisms of herbal medicines.
背景
肉苁蓉对治疗肾虚证（Shenxu Zheng）具有疗效。然而，其治疗作用的机制和系统代谢反应尚不清楚。
方法
采用基于 GC-MS 的代谢组学方法，我们研究了肉苁蓉干预氢化可的松诱导的肾虚证大鼠模型的代谢反应。
结果
氢化可的松注射后的大鼠代谢谱在不同时间点（从第 1 天到第 10 天）偏离了预剂量代谢状态，而同时接受氢化可的松和肉苁蓉水提物治疗的大鼠的代谢谱在第 10 天恢复到预剂量状态。
结论
肉苁蓉的干预作用导致大鼠的氢化可的松诱导的代谢紊乱得到了全身性的恢复。本研究还表明，代谢组学在研究草药治疗机制方面是有用的。
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