Department of Neurology, Medical University, Sofia, Bulgaria.
Am J Alzheimers Dis Other Demen. 2010 Aug;25(5):455-60. doi: 10.1177/1533317510370956. Epub 2010 May 19.
Recent studies suggest that onset of dementia in Parkinson's disease (PD) is preceded by a phase known as mild cognitive impairment (MCI). Different clinical subtypes of MCI in PD were found. The objective of this study was to investigate whether patients with PD diagnosed with amnestic MCI (aPD-MCI) have also subtle deficits in other cognitive domains and especially in attention/executive functions and, therefore to clarify whether all subcomponents of executive control are equally affected in aPD-MCI. We investigated 23 patients with aPD-MCI (modified Petersen's criteria) and 25 normal controls. Relative to controls, the aPD-MCI group showed significant deficits with reference to tasks that encompass various aspects of attention/executive functions, including Trail Making Test, Stroop test, Modified Card Sorting Test, and digit span backward, as well as phonemic and semantic verbal fluency. This suggests that executive dysfunction is consistently presented in PD with MCI, even in ''amnestic'' PD-MCI due to cortical-subcortical dysfunction.
最近的研究表明，帕金森病（PD）患者的痴呆症发作前会经历一个被称为轻度认知障碍（MCI）的阶段。在 PD 中发现了不同的 MCI 临床亚型。本研究的目的是探讨诊断为遗忘型轻度认知障碍（aPD-MCI）的 PD 患者是否在其他认知领域，特别是在注意力/执行功能方面也存在细微缺陷，以及是否所有执行控制的亚成分在 aPD-MCI 中受到同等影响。我们调查了 23 名患有 aPD-MCI（改良的彼得森标准）和 25 名正常对照者。与对照组相比，aPD-MCI 组在包含注意力/执行功能各个方面的任务中表现出明显的缺陷，包括连线测试、斯特鲁普测试、改良卡片分类测试和数字广度倒背测试，以及语音和语义流畅性测试。这表明，即使是由于皮质下功能障碍导致的“遗忘型”PD-MCI，执行功能障碍也会在 MCI 的 PD 中持续存在。
