Hildebrandt Helmut, Fink Frauke, Kastrup Andreas, Haupts Michael, Eling Paul
Department of Neurology, Klinikum Bremen-Ost, Bremen, University of Oldenburg, Oldenburg ; Institute of Psychology, University of Oldenburg, Oldenburg.
Dement Geriatr Cogn Dis Extra. 2013 Apr 3;3(1):102-12. doi: 10.1159/000348350. Print 2013 Jan.
Alzheimer's disease (AD) and Parkinson's disease (PD) are associated with severe cognitive decline, but it is still unclear to what extent they become functionally more similar over time.
We compared amnestic mild cognitively impaired (aMCI; n = 29) patients to mild cognitively impaired (MCI) PD patients (n = 25), and patients with AD (n = 34) to patients with PD dementia (PDD; n = 15) with respect to cognitive functioning and mood.
aMCI patients were impaired in episodic memory, while MCI PD patients showed deficits in visuoconstruction and attention. AD and PDD patients showed comparable deficits on tests for language, attention and visuoconstruction. However, unlike PDD patients but similar to aMCI patients, AD patients showed a characteristic memory impairment, especially commission errors on recognition tasks, whereas PDD patients scored higher on the depressive mood questionnaire.
In advanced stages of both diseases, the pattern of functional deficits associated with parietal and temporal lobe functions (attention, visuoconstruction and language) is similar. However, specific differences, already present in the early stage (recognition errors in AD, associated with mediobasal temporal lobe functioning, and depressed mood in PDD, associated with non-motor basal ganglia loops), are also observed in the late stage.
阿尔茨海默病（AD）和帕金森病（PD）与严重的认知衰退相关，但它们在功能上随时间推移变得更加相似的程度仍不清楚。
我们比较了遗忘型轻度认知障碍（aMCI；n = 29）患者与轻度认知障碍（MCI）的PD患者（n = 25），以及AD患者（n = 34）与帕金森病痴呆（PDD；n = 15）患者在认知功能和情绪方面的差异。
aMCI患者在情景记忆方面受损，而MCI的PD患者在视空间构建和注意力方面存在缺陷。AD和PDD患者在语言、注意力和视空间构建测试中表现出相当的缺陷。然而，与PDD患者不同但与aMCI患者相似的是，AD患者表现出特征性的记忆障碍，尤其是在识别任务中的误判错误，而PDD患者在抑郁情绪问卷上得分更高。
在这两种疾病的晚期，与顶叶和颞叶功能（注意力、视空间构建和语言）相关的功能缺陷模式相似。然而，在早期就已存在的特定差异（AD中的识别错误，与颞叶内侧基底功能相关；PDD中的抑郁情绪，与非运动性基底神经节环路相关）在晚期也能观察到。
