绝经后女性心血管风险状态下的血浆游离脂肪酸水平模式

Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women.

作者信息

Rhee Yumie, Paik Man-Jeong, Kim Kyoung-Rae, Ko Young-Guk, Kang Eun Seok, Cha Bong Soo, Lee Hyun Chul, Lim Sung-Kil

机构信息

Department of Internal Medicine & Endocrine Research Institute, College of Medicine, Yonsei University, Seoul, Republic of Korea.

出版信息

Clin Chim Acta. 2008 Jun;392(1-2):11-6. doi: 10.1016/j.cca.2008.02.012. Epub 2008 Feb 16.

DOI:10.1016/j.cca.2008.02.012

PMID:18328818

Abstract

BACKGROUND

The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women.

METHODS

The participants were as follows; premenopausal women (PRE, n=20) and postmenopausal women without any known chronic disease (POST, n=35), with DM (DM, n=35), or with angiographically proven CHD (CHD, n=30). Plasma free fatty acids were measured in all participants.

RESULTS

Healthy premenopausal women had a higher ratio of omega-3/omega-6 PUFA than postmenopausal women (p=0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p<0.05) and lower arachidonic acid levels (p<0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p<0.05). There were significant shifts of increased omega-6 and decreased omega-3 among the women, according to each disease.

CONCLUSIONS

There was a significant relationship between omega-3 and omega-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.

摘要

背景

本研究调查了韩国女性血浆游离多不饱和脂肪酸（PUFA）模式随绝经状态以及糖尿病（DM）或冠心病（CHD）的存在情况而发生的变化。

方法

参与者如下：绝经前女性（PRE，n = 20）以及无任何已知慢性病的绝经后女性（POST，n = 35）、患有DM的绝经后女性（DM，n = 35）或经血管造影证实患有CHD的绝经后女性（CHD，n = 30）。对所有参与者测量血浆游离脂肪酸。

结果

健康的绝经前女性的ω-3/ω-6 PUFA比值高于绝经后女性（p = 0.001）。正如预期的那样，PRE组的二十二碳五烯酸（DPA）和二十二碳六烯酸（DHA）水平高于POST组（p < 0.05），而花生四烯酸水平低于POST组（p < 0.05）。相应地，健康的POST组与DM组或CHD组相比，DPA和DHA水平更高（p < 0.05）。根据每种疾病情况，女性体内ω-6增加而ω-3减少的情况有显著变化。