Wang Xin, Zhang FaMing, Liu ZhenXiong, Feng HanZhong, Yu Zhi Bin, Lu Yuanyuan, Zhai HuiHong, Bai FeiHu, Shi YongQuan, Lan Mei, Jin JianPing, Fan DaiMing
State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changle West Road, Xi'an 710032, China.
J Ethnopharmacol. 2008 Apr 17;117(1):102-7. doi: 10.1016/j.jep.2008.01.023. Epub 2008 Feb 3.
Croton tiglium (Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies established its purgative and inflammational properties. The present study aimed to investigate the effects of Croton tiglium oil (CO) on intestinal transit in mice.
Gastrointestinal transit in mice and contractile characteristics of isolated intestinal strips from mice were evaluated. Intestinal inflammation was confirmed by histological examination.
Low dose of CO increased the gastrointestinal transit of charcoal and barium meal as well as the production of fecal pellets in mice. In contrast, high dose exerted inhibitory effects. For normal colonic circular strips, both high and low dose of CO inhibited the contractile frequency. Low doses (0-20 microg/ml) of CO enhanced the phasic contractions, while high doses (>40 microg/ml) reduced them. Colonic longitudinal strips in CO-treated mice were less sensitive to electrical field stimulation than those in control mice. The contraction of colonic longitudinal, colonic and jejunal circular strips in CO-treated mice was more sensitive to atropine than that in control mice.
CO might modulate gastrointestinal motility and induce intestinal inflammation related to immunological milieu and motor activity. Our findings may highlight the ethno-medical uses of Croton tiglium on intestinal disorders.
巴豆（巴豆属大戟科植物）被广泛用作治疗胃肠道紊乱的草药。先前的研究证实了其泻下和抗炎特性。本研究旨在探讨巴豆油（CO）对小鼠肠道转运的影响。
评估小鼠的胃肠道转运以及从小鼠分离的肠条的收缩特性。通过组织学检查确认肠道炎症。
低剂量的CO增加了小鼠中木炭和钡餐的胃肠道转运以及粪便颗粒的产生。相反，高剂量则产生抑制作用。对于正常结肠环行肌条，高剂量和低剂量的CO均抑制收缩频率。低剂量（0 - 20微克/毫升）的CO增强了节律性收缩，而高剂量（>40微克/毫升）则降低了节律性收缩。与对照小鼠相比，经CO处理的小鼠结肠纵行肌条对电场刺激的敏感性较低。与对照小鼠相比，经CO处理的小鼠结肠纵行肌、结肠和空肠环行肌条的收缩对阿托品更敏感。
CO可能调节胃肠动力，并引发与免疫环境和运动活性相关的肠道炎症。我们的研究结果可能突出了巴豆在肠道疾病方面的民族医学用途。
