Zeng Bao, Huang Meng-Qiu, Tang Jun-Ping, Xiao Zu-Ping, Jiang Dong-Xu, Lai Xiao-Ping
Research Institute of Mathematical Engineering of Guangzhou University of Chinese Medicine, Dongguan 523808, China.
Zhong Yao Cai. 2012 Mar;35(3):371-5.
To build a new processing procedure for Croton tiglium, providing a more simple, efficient and safe way of processing.
Used the contents of isoguanosine and toxic protein in Croton tiglium as the indexes to investigate the effect of different temperature, thickness and baked time on processing for Croton tiglium. After established all factors and levels, processed a batch of Croton tiglium under optimum processing conditions and compared it with raw Croton tiglium in the test of acute toxicity and gastrointestinal propulsive motility.
The parameters of optimum processing were as follows:the temperature was set at 180 degrees C, the thickness of placement was 3 cm and baked time was 90 min. The LD50 value of raw Croton tiglium and the processed Croton tiglium was 888 mg/kg and 2139 mg/kg respectively.
The processing procedure is simple, affordable, safe and efficient, deserved to promote for application.
建立一种巴豆的新炮制方法，提供一种更简便、高效且安全的炮制方式。
以巴豆中异鸟苷和毒蛋白的含量为指标，考察不同温度、厚度及烘烤时间对巴豆炮制的影响。确定所有因素及水平后，在最佳炮制条件下炮制一批巴豆，并与生巴豆进行急性毒性试验和胃肠推进运动试验比较。
最佳炮制参数如下：温度设定为180℃，放置厚度为3cm，烘烤时间为90分钟。生巴豆和炮制后巴豆的半数致死量（LD50）值分别为888mg/kg和2139mg/kg。
该炮制方法简便、经济、安全且高效，值得推广应用。
