Caplan Jeffrey, Padmanabhan Meenu, Dinesh-Kumar Savithramma P
Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT 06520-8103, USA.
Cell Host Microbe. 2008 Mar 13;3(3):126-35. doi: 10.1016/j.chom.2008.02.010.
Both plants and animals contain nucleotide-binding domain and leucine-rich repeat (NB-LRR)-type immune receptors that function during defense against pathogens. Unlike animal NB-LRRs that recognize general pathogen or microbe-associated molecular patterns (PAMPs or MAMPs), plant NB-LRR immune receptors have evolved the ability to specifically recognize a wide range of effector proteins from different pathogens. Recent research has revealed that plant NB-LRRs are incredibly adaptive in their ways of pathogen recognition and defense initiation. This review focuses on the remarkable variety of functions, recognition mechanisms, subcellular localizations, and host factors associated with plant NB-LRR immune receptors.
植物和动物都含有核苷酸结合结构域和富含亮氨酸重复序列（NB-LRR）型免疫受体，它们在抵御病原体的过程中发挥作用。与识别一般病原体或微生物相关分子模式（PAMP或MAMP）的动物NB-LRR不同，植物NB-LRR免疫受体已经进化出特异性识别来自不同病原体的多种效应蛋白的能力。最近的研究表明，植物NB-LRR在病原体识别和防御启动方式上具有令人难以置信的适应性。本综述重点关注与植物NB-LRR免疫受体相关的功能、识别机制、亚细胞定位和宿主因子的显著多样性。
