Padmanabhan Meenu, Cournoyer Patrick, Dinesh-Kumar S P
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA.
Cell Microbiol. 2009 Feb;11(2):191-8. doi: 10.1111/j.1462-5822.2008.01260.x. Epub 2008 Nov 3.
The innate immune system of both plants and animals uses immune receptors to detect pathogens and trigger defence responses. Despite having distinct evolutionary origin, most plant and animal immune receptors have a leucine-rich repeat (LRR) domain. The LRR domain adopts a slender conformation that maximizes surface area and has been shown to be ideal for mediating protein-protein interactions. Although the LRR domain was expected to be a platform for pathogen recognition, the NB-LRR class of plant innate immune receptors uses its LRR domain to carry out many other roles. This review discusses the domain architecture of plant LRRs and the various roles ascribed to this motif.
植物和动物的先天免疫系统都利用免疫受体来检测病原体并触发防御反应。尽管植物和动物的免疫受体有着不同的进化起源，但大多数植物和动物免疫受体都有一个富含亮氨酸的重复（LRR）结构域。LRR结构域呈细长构象，能使表面积最大化，并且已被证明是介导蛋白质-蛋白质相互作用的理想结构。尽管LRR结构域被认为是病原体识别的平台，但植物先天免疫受体中的NB-LRR类利用其LRR结构域来发挥许多其他作用。本文综述了植物LRR的结构域架构以及赋予该基序的各种作用。
